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Sökning: onr:"swepub:oai:DiVA.org:oru-49331" > Analysis of five ch...

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Ellinghaus, David (författare)
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
Jostins, Luke (författare)
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
Spain, Sarah L. (författare)
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
visa fler...
Cortes, Adrian (författare)
Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Bethune, Jörn (författare)
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
Han, Buhm (författare)
Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea
Park, Yu Rang (författare)
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
Raychaudhuri, Soumya (författare)
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States
Pouget, Jennie G. (författare)
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada
Hübenthal, Matthias (författare)
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
Folseraas, Trine (författare)
Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway
Wang, Yunpeng (författare)
Department of Neurosciences, University of California, San Diego, USA
Esko, Tonu (författare)
Estonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Boston Children's Hospital, Cambridge MA, USA; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, USA
Metspalu, Andres (författare)
Estonian Genome Center, University of Tartu, Tartu, Estonia
Westra, Harm-Jan (författare)
Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States; Department of Medicine, Harvard Medical School, Boston MA, United States
Franke, Lude (författare)
University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, the Netherlands
Pers, Tune H. (författare)
Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, United States; Novo Nordisk Foundation, Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Weersma, Rinse K. (författare)
Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands
Collij, Valerie (författare)
Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands
D'Amato, Mauro (författare)
Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden; BioCruces Health Research Institute, Basque Foundation for Science (Ikerbasque), Bilbao, Spain
Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Jensen, Anders Boeck (författare)
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Lieb, Wolfgang (författare)
Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany; PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany
Degenhardt, Franziska (författare)
Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Forstner, Andreas J. (författare)
Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Hofmann, Andrea (författare)
Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
The International IBD Genetics Consortium, (IIBDGC) (författare)
International Genetics of Ankylosing Spondylitis Consortium, (IGAS) (författare)
International PSC Study Group, (IPSCSG) (författare)
Genetic Analysis of Psoriasis Consortium, (GAPC) (författare)
Psoriasis Association Genetics Extension, (PAGE) (författare)
Schreiber, Stefan (författare)
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Mrowietz, Ulrich (författare)
Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany
Juran, Brian D. (författare)
Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA
Lazaridis, Konstantinos N. (författare)
Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA
Brunak, Søren (författare)
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Dale, Anders M. (författare)
Department of Neurosciences, University of California, San Diego, USA; Department of Radiology, University of California, San Diego, USA
Trembath, Richard C. (författare)
Division of Genetics and Molecular Medicine, King's College London, London, UK
Weidinger, Stephan (författare)
Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany
Weichenthal, Michael (författare)
Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany
Ellinghaus, Eva (författare)
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
Elder, James T. (författare)
Department of Dermatology, University of Michigan, Ann Arbor, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, USA
Barker, Jonathan N. W. N. (författare)
St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK
Andreassen, Ole A. (författare)
NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital Ullevål, Oslo, Norway
McGovern, Dermot P. (författare)
F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, USA; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, USA
Karlsen, Tom H. (författare)
Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway
Barrett, Jeffrey C. (författare)
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
Parkes, Miles (författare)
Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
Brown, Matthew A. (författare)
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane QLD, Australia; Institute of Health and Biomedical Innovation (IHBI), Translational Research Institute, Queensland University of Technology (QUT), Brisbane QLD, Australia
Franke, Andre (författare)
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
Schreiber, S (författare)
Cortes, A (författare)
Pers, TH (författare)
Elder, JT (författare)
Hofmann, A (författare)
Bethune, J (författare)
Franke, L (författare)
Karlsen, TH (författare)
Hubenthal, M (författare)
Dale, AM (författare)
McGovern, DP (författare)
Metspalu, A (författare)
Weichenthal, M (författare)
Wang, YP (författare)
Brunak, S (författare)
Weidinger, S (författare)
Parkes, M (författare)
Weersma, RK (författare)
Collij, V (författare)
Halfvarson, J (författare)
Barker, JNWN (författare)
Park, YR (författare)
D'Amato, M (författare)
Karolinska Institutet
Han, B (författare)
Trembath, RC (författare)
Raychaudhuri, S (författare)
Degenhardt, F (författare)
Juran, BD (författare)
Esko, T (författare)
Ellinghaus, D (författare)
Jensen, AB (författare)
Barrett, JC (författare)
Westra, HJ (författare)
Ellinghaus, E (författare)
Pouget, JG (författare)
Lazaridis, KN (författare)
Spain, SL (författare)
Brown, MA (författare)
Forstner, AJ (författare)
Lieb, W (författare)
Franke, A (författare)
Andreassen, OA (författare)
Folseraas, T (författare)
Mrowietz, U (författare)
Jostins, L (författare)
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 (creator_code:org_t)
New York, USA : Nature Publishing Group, 2016
2016
Engelska.
Ingår i: Nature Genetics. - New York, USA : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 48:5, s. 510-518
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

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Genetics

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Av författaren/redakt...
Ellinghaus, Davi ...
Jostins, Luke
Spain, Sarah L.
Cortes, Adrian
Bethune, Jörn
Han, Buhm
visa fler...
Park, Yu Rang
Raychaudhuri, So ...
Pouget, Jennie G ...
Hübenthal, Matth ...
Folseraas, Trine
Wang, Yunpeng
Esko, Tonu
Metspalu, Andres
Westra, Harm-Jan
Franke, Lude
Pers, Tune H.
Weersma, Rinse K ...
Collij, Valerie
D'Amato, Mauro
Halfvarson, Jona ...
Jensen, Anders B ...
Lieb, Wolfgang
Degenhardt, Fran ...
Forstner, Andrea ...
Hofmann, Andrea
The Internationa ...
International Ge ...
International PS ...
Genetic Analysis ...
Psoriasis Associ ...
Schreiber, Stefa ...
Mrowietz, Ulrich
Juran, Brian D.
Lazaridis, Konst ...
Brunak, Søren
Dale, Anders M.
Trembath, Richar ...
Weidinger, Steph ...
Weichenthal, Mic ...
Ellinghaus, Eva
Elder, James T.
Barker, Jonathan ...
Andreassen, Ole ...
McGovern, Dermot ...
Karlsen, Tom H.
Barrett, Jeffrey ...
Parkes, Miles
Brown, Matthew A ...
Franke, Andre
Schreiber, S
Cortes, A
Pers, TH
Elder, JT
Hofmann, A
Bethune, J
Franke, L
Karlsen, TH
Hubenthal, M
Dale, AM
McGovern, DP
Metspalu, A
Weichenthal, M
Wang, YP
Brunak, S
Weidinger, S
Parkes, M
Weersma, RK
Collij, V
Halfvarson, J
Barker, JNWN
Park, YR
D'Amato, M
Han, B
Trembath, RC
Raychaudhuri, S
Degenhardt, F
Juran, BD
Esko, T
Ellinghaus, D
Jensen, AB
Barrett, JC
Westra, HJ
Ellinghaus, E
Pouget, JG
Lazaridis, KN
Spain, SL
Brown, MA
Forstner, AJ
Lieb, W
Franke, A
Andreassen, OA
Folseraas, T
Mrowietz, U
Jostins, L
visa färre...
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och Medicinsk geneti ...
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och Medicinska och f ...
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