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Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma : correlation with clinical outcome

Graflund, M., (författare)
Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden
Sorbe, Bengt, 1947- (författare)
Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden
Sigurdardóttir, S., (författare)
Department of Pathology, Örebro University Hospital, Örebro, Sweden
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Karlsson, Mats G., 1960- (författare)
Department of Pathology, Örebro University Hospital, Örebro, Sweden
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2004
Engelska.
Ingår i: Oncology Reports. - Athens, Greece : Spandidos Publications. - 1021-335X. ; 12:1, s. 169-176
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The purpose of the present study was to analyze the relation between the expression of p53, bcl-2, p21WAF1, MIB-1, HER-2/neu, DNA ploidy and HPV16 or 18 infections with clinical parameters. HPV-DNA was evaluated in 171 early cervical carcinomas treated from 1965 to 1990 and detected by PCR (polymerase chain reaction) on paraffin specimens obtained before therapy was started. HPV-DNA of any type was detected in 78% (86/110) of all tumors, HPV16 was the predominant type and was seen in 56% (62/110), HPV18 in 8% (9/110) and HPV35 in 21% (23/110). Patients with HPV16 or 18 were significantly (P=0.011) younger than patients with tumors not containing these two HPV subtypes. Lymph node metastases were seen more frequently (P=0.047) in tumors expressing HPV16 or 18. Tumor size was associated with the HPV-type. The frequency of DNA aneuploidy was lower in high-risk HPV tumors than in tumors with other HPV subtypes (P=0.014). MIB-1 expression was highly significantly (P=0.00007) associated with presence of HPV16 or 18. The cancer-specific survival rate was lower for patients with HPV16 and 18 positive tumors, but the difference was not statistically significant. The overall 5-year survival rate of the complete series was 91%. In conclusion, the HPV DNA subtype was a prognostic factor in early stage cervical cancer and it was associated with age, positive lymph nodes, tumor size, DNA ploidy and the proliferation marker MIB-1.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Nyckelord

Cervical cancer
human papillomavirus
DNA ploidy
p53
bcl-2; p21(WAF1)
MIB-1
HER-2/neu
prognostic factors

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Av författaren/redakt...
Graflund, M.
Sorbe, Bengt, 19 ...
Sigurdardóttir, ...
Karlsson, Mats G ...
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Cancer och onkol ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Klinisk laborato ...
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Oncology Reports
Av lärosätet
Örebro universitet

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