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FältnamnIndikatorerMetadata
00004744nam a2200613 4500
001oai:DiVA.org:oru-51438
003SwePub
008160725s2016 | |||||||||||000 ||eng|
020 a 9789175291536q print
024a urn:nbn:se:oru:diva-514382 urn
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a dok2 swepub-publicationtype
100a Humble, Mats B.,d 1952-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)mhe
2451 0a Obsessive-compulsive disorder, serotonin and oxytocin :b treatment response and side effects
264 1a Örebro :b Örebro university,c 2016
300 a 133s.
338 a electronic2 rdacarrier
490a Örebro Studies in Medicine,x 1652-4063 ;v 148
506 a gratis
506 a gratis
506 a gratis
506 a gratis
520 a Obsessive-compulsive disorder (OCD), with a prevalence of 1-2 %, frequently leads a chronic course. Persons with OCD are often reluctant to seek help and, if they do, their OCD is often missed. This is unfortunate, since active treatment may substantially improve social function and quality of life. Serotonin reuptake inhibitors (SRIs) have welldocumented efficacy in OCD, but delayed response may be problematic. Methods to predict response have been lacking. Because SRIs are effective, pathophysiological research on OCD has focussed on serotonin. However, no clear aberrations of serotonin have been found, thus other mechanisms ought to be involved.Our aims were to facilitate clinical detection and assessment of OCD, to search for biochemical correlates of response and side-effects in SRI treatment of OCD and to identify any possible involvement of oxytocin in the pathophysiology of OCD.In study I, we tested in 402 psychiatric out-patients the psychometric properties of a concise rating scale, “Brief Obsessive Compulsive Scale” (BOCS). BOCS was shown to be easy to use and have excellent discriminant validity in relation to other common psychiatric diagnoses.Studies II-V were based on 36 OCD patients from a randomised controlled trial of paroxetine, clomipramine or placebo. In study II, contrary to expectation, we found that the change (decrease) of serotonin in whole blood was most pronounced in non-responders to SRI. This is likely to reflect inflammatory influence on platelet turnover rather than serotonergic processes within the central nervous system.In studies IV-V, we found relations between changes of oxytocin in plasma and the anti-obsessive response, and between oxytocin and the SRI related delay of orgasm, respectively. In both cases, the relation to central oxytocinergic mechanisms is unclear. In males, delayed orgasm predicted anti-obsessive response.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Adverse effects
653 a Obsessive-compulsive disorder
653 a Orgasm
653 a Oxytocin
653 a Randomised controlled trial
653 a Rating scale
653 a Response prediction
653 a Serotonin
653 a Serotonin uptake inhibitors
653 a Sexual function
653 a Psychiatry
653 a Psykiatri
700a Engström, Ingemar,c Adjungerad professoru Örebro universitet,Institutionen för medicinska vetenskaper4 ths0 (Swepub:oru)iem
700a von Knorring, Lars,c Professoru Uppsala universitet4 ths
700a Kjellin, Lars,c Docentu Örebro universitet,Institutionen för hälsovetenskaper4 ths0 (Swepub:oru)lkn
700a Träskman-Bendz, Lil,c Professoru Institutionen för kliniska vetenskaper, Lunds universitet4 opn
710a Örebro universitetb Institutionen för medicinska vetenskaper4 org
856u http://oru.diva-portal.org/smash/get/diva2:949869/PREVIEW01.png
856u http://oru.diva-portal.org/smash/get/diva2:949869/COVER01.pdf
856u http://oru.diva-portal.org/smash/get/diva2:949869/FULLTEXT01.pdfx primary
856u http://oru.diva-portal.org/smash/get/diva2:949869/SPIKBLAD01.pdf
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51438x lärosäteslänky Till lärosätets (oru) databas

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