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Sökning: onr:"swepub:oai:DiVA.org:oru-53356" > Development of an i...

Development of an index to define overall disease severity in IBD

Siegel, Corey A. (författare)
Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon NH, USA
Whitman, Cynthia B. (författare)
Department of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA
Spiegel, Brennan M. R. (författare)
Department of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA
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Feagan, Brian (författare)
Department of Health Services, Cedars-Sinai Medical Center, Los Angeles California, USA
Sands, Bruce (författare)
Icahn School of Medicine at Mount Sinai, New York, USA
Loftus, Edward V., Jr (författare)
Mayo Clinic, Rochester MN, USA
Panaccione, Remo (författare)
University of Calgary, Calgary AB, Canada
D'Haens, Geert (författare)
Academic Medical Center, Amsterdam, Netherlands
Bernstein, Charles N. (författare)
University of Manitoba, Winnipeg MB, Canada
Gearry, Richard (författare)
University of Otago, Christchurch, New Zealand
Ng, Siew C. (författare)
Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
Mantzaris, Gerassimos J. (författare)
Evangelismos-PolyCliniki-Ophthalmiatreion Hospital, Athens, Greece
Sartor, Balfour (författare)
University of North Carolina, Chapel Hill NC, USA
Silverberg, Mark S. (författare)
Mount Sinai Hospital, Toronto ON, Canada
Riddell, Robert (författare)
Mount Sinai Hospital, Toronto ON, Canada
Koutroubakis, Ioannis E. (författare)
University Hospital Heraklion, Crete, Greece
O'Morain, Colm (författare)
Faculty of Health Sciences Trinity College Dublin, Dublin, Ireland
Lakatos, Peter L. (författare)
Semmelweis University, Budapest, Hungary
McGovern, Dermot P. B. (författare)
Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai, Medical Center, Los Angeles CA, USA
Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
Reinisch, Walter (författare)
McMaster University, Hamilton ON, Canada
Rogler, Gerhard (författare)
University Hospital of Zuürich, Zurich, Switzerland
Kruis, Wolfgang (författare)
University of Cologne, Koln, Germany
Tysk, Curt, 1949- (författare)
Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Schreiber, Stefan (författare)
University Hopital Schleswig Holstein, Kiel, Germany
Danese, Silvio (författare)
Humanitas University, Milan, Italy
Sandborn, William (författare)
UCSD, San Diego CA, USA
Griffiths, Anne (författare)
Hospital for Sick Children, Toronto ON, Canada
Moum, Bjorn (författare)
Oslo University Hospital and University Oslo, Oslo, Norway
Gasche, Christoph (författare)
Medical University and General Hospital Vienna, Vienna, Austria
Pallone, Francesco (författare)
University of Rome Tor Vergata, Rome, Italy
Travis, Simon (författare)
Oxford University Hospital, Oxford, UK
Panes, Julian (författare)
Hospital Clinic de Barcelona, Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
Colombel, Jean-Frederic (författare)
Icahn School of Medicine at Mount Sinai, New York, USA
Hanauer, Stephen (författare)
Northwestern Feinberg School of Medicine, Chicago IL, USA
Peyrin-Biroulet, Laurent (författare)
Inserm U954 and Centre Hospitaliers Régionaux et Universitaires (CHU) de Nancy, Lorraine University, Nancy, France
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 (creator_code:org_t)
London, United Kingdom : BMJ Publishing Group Ltd, 2018
2018
Engelska.
Ingår i: Gut. - London, United Kingdom : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 67:2, s. 244-254
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background and aim: Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining overall disease severity, to rank the importance of and to score these individual attributes for both CD and UC.Methods: Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute.Results: For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities.Conclusions: Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Crohn's Disease
IBD
Ulcerative Colitis

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