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Sökning: onr:"swepub:oai:DiVA.org:oru-53356" > Development of an i...

  • Siegel, Corey A.Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon NH, USA (författare)

Development of an index to define overall disease severity in IBD

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • London, United Kingdom :BMJ Publishing Group Ltd,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-53356
  • urn:nbn:se:oru:diva-53356urn
  • https://doi.org/10.1136/gutjnl-2016-312648DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • <p>Funding Agencies:</p><p>AbbVie  </p><p>Tillotts </p>
  • Background and aim: Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining overall disease severity, to rank the importance of and to score these individual attributes for both CD and UC.Methods: Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute.Results: For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities.Conclusions: Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Whitman, Cynthia B.Department of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA (författare)
  • Spiegel, Brennan M. R.Department of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA (författare)
  • Feagan, BrianDepartment of Health Services, Cedars-Sinai Medical Center, Los Angeles California, USA (författare)
  • Sands, BruceIcahn School of Medicine at Mount Sinai, New York, USA (författare)
  • Loftus, Edward V.,JrMayo Clinic, Rochester MN, USA (författare)
  • Panaccione, RemoUniversity of Calgary, Calgary AB, Canada (författare)
  • D'Haens, GeertAcademic Medical Center, Amsterdam, Netherlands (författare)
  • Bernstein, Charles N.University of Manitoba, Winnipeg MB, Canada (författare)
  • Gearry, RichardUniversity of Otago, Christchurch, New Zealand (författare)
  • Ng, Siew C.Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China (författare)
  • Mantzaris, Gerassimos J.Evangelismos-PolyCliniki-Ophthalmiatreion Hospital, Athens, Greece (författare)
  • Sartor, BalfourUniversity of North Carolina, Chapel Hill NC, USA (författare)
  • Silverberg, Mark S.Mount Sinai Hospital, Toronto ON, Canada (författare)
  • Riddell, RobertMount Sinai Hospital, Toronto ON, Canada (författare)
  • Koutroubakis, Ioannis E.University Hospital Heraklion, Crete, Greece (författare)
  • O'Morain, ColmFaculty of Health Sciences Trinity College Dublin, Dublin, Ireland (författare)
  • Lakatos, Peter L.Semmelweis University, Budapest, Hungary (författare)
  • McGovern, Dermot P. B.Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai, Medical Center, Los Angeles CA, USA (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)jshn (författare)
  • Reinisch, WalterMcMaster University, Hamilton ON, Canada (författare)
  • Rogler, GerhardUniversity Hospital of Zuürich, Zurich, Switzerland (författare)
  • Kruis, WolfgangUniversity of Cologne, Koln, Germany (författare)
  • Tysk, Curt,1949-Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
  • Schreiber, StefanUniversity Hopital Schleswig Holstein, Kiel, Germany (författare)
  • Danese, SilvioHumanitas University, Milan, Italy (författare)
  • Sandborn, WilliamUCSD, San Diego CA, USA (författare)
  • Griffiths, AnneHospital for Sick Children, Toronto ON, Canada (författare)
  • Moum, BjornOslo University Hospital and University Oslo, Oslo, Norway (författare)
  • Gasche, ChristophMedical University and General Hospital Vienna, Vienna, Austria (författare)
  • Pallone, FrancescoUniversity of Rome Tor Vergata, Rome, Italy (författare)
  • Travis, SimonOxford University Hospital, Oxford, UK (författare)
  • Panes, JulianHospital Clinic de Barcelona, Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain (författare)
  • Colombel, Jean-FredericIcahn School of Medicine at Mount Sinai, New York, USA (författare)
  • Hanauer, StephenNorthwestern Feinberg School of Medicine, Chicago IL, USA (författare)
  • Peyrin-Biroulet, LaurentInserm U954 and Centre Hospitaliers Régionaux et Universitaires (CHU) de Nancy, Lorraine University, Nancy, France (författare)
  • Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon NH, USADepartment of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:GutLondon, United Kingdom : BMJ Publishing Group Ltd67:2, s. 244-2540017-57491468-3288

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  • Gut (Sök värdpublikationen i LIBRIS)

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