SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-54661"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-54661" > Paternal age at chi...

Paternal age at childbirth and eating disorders in offspring

Javaras, K N, (författare)
Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA
Rickert, M E, (författare)
Department of Psychological and Brain Sciences, Indiana University, Bloomington IN, USA
Thornton, L M, (författare)
Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA
visa fler...
Peat, C M, (författare)
Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA; Department of Neurosurgery, University of North Carolina, Chapel Hill NC, USA
Baker, J H, (författare)
Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA
Birgegård, A, (författare)
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Norring, C, (författare)
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Landén, M, (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Almqvist, C, (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children’ s Hospital, Karolinska University Hospital, Stockholm, Sweden
Larsson, Henrik, 1975- (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Lichtenstein, P, (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Bulik, C M, (författare)
Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina, Chapel Hill NC, USA
D'Onofrio, B M, (författare)
Department of Psychological and Brain Sciences, Indiana University, Bloomington IN, USA
Birgegard, A. (författare)
Landen, M. (författare)
visa färre...
Karolinska Institutet Inst för medicinsk epidemiologi och biostatistik. 
2017
Engelska.
Ingår i: Psychological Medicine. - Cambridge University Press. - 0033-2917. ; 47:3, s. 576-584
Läs hela texten (fulltext)
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age's relationship with eating disorders in offspring. In a large, population-based cohort, we examined the association between paternal age and offspring eating disorders, and whether that association remains after adjustment for potential confounders (e.g. parental education level) that may be related to late/early selection into fatherhood and to eating disorder incidence.METHOD: Data for 2 276 809 individuals born in Sweden 1979-2001 were extracted from Swedish population and healthcare registers. The authors used Cox proportional hazards models to examine the effect of paternal age on the first incidence of healthcare-recorded anorexia nervosa (AN) and all eating disorders (AED) occurring 1987-2009. Models were adjusted for sex, birth order, maternal age at childbirth, and maternal and paternal covariates including country of birth, highest education level, and lifetime psychiatric and criminal history.RESULTS: Even after adjustment for covariates including maternal age, advanced paternal age was associated with increased risk, and younger paternal age with decreased risk, of AN and AED. For example, the fully adjusted hazard ratio for the 45+ years (v. the 25-29 years) paternal age category was 1.32 [95% confidence interval (CI) 1.14-1.53] for AN and 1.26 (95% CI 1.13-1.40) for AED.CONCLUSIONS: In this large, population-based cohort, paternal age at childbirth was positively associated with eating disorders in offspring, even after adjustment for potential confounders. Future research should further explore potential explanations for the association, including de novo mutations in the paternal germline.

Ämnesord

SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

Psychology
Psykologi
Psychiatry
Psykiatri
Anorexia nervosa
eating disorders
paternal age

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy