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Sökning: onr:"swepub:oai:DiVA.org:oru-56326" > The prognostic role...

The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study

Borgquist, Signe, (författare)
Dept Clin Sci, Div Oncol & Pathol, Lund Univ, Lund, Sweden
Zhou, Wenjing, (författare)
Dept Surg Sci, Uppsala Univ, Uppsala, Sweden
Jirstrom, Karin, (författare)
Dept Clin Sci, Div Oncol & Pathol, Lund Univ, Lund, Sweden
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Amini, Rose-Marie, (författare)
Dept Genet & Pathol, Uppsala Univ, Uppsala, Sweden
Sollie, Thomas, (författare)
Dept Pathol, Örebro University Hospital, Örebro, Sweden
Sorlie, Therese, (författare)
Norwegian Radium Hosp, Inst Canc Res, Dept Genet, Oslo Univ Hosp, Oslo, Norway
Blomqvist, Carl, (författare)
Cent Hosp, Dept Oncol, Univ Helsinki, Helsinki, Finland
Butt, Salma, (författare)
Dept Surg, Lund Univ, Malmö, Sweden
Warnberg, Fredrik, (författare)
Dept Surg Sci, Uppsala Univ, Uppsala, Sweden
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2015
Engelska.
Ingår i: BMC Cancer. - BioMed Central. - 1471-2407 .- 1471-2407. ; 15
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>Background: HER2 is a well-established prognostic and predictive factor in invasive breast cancer. The role of HER2 in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that HER2 is mainly related to in situ recurrences. Our aim was to study HER2 as a prognostic factor in a large population based cohort of DCIS with long-term follow-up. Methods: All 458 patients diagnosed with a primary DCIS 1986-2004 in two Swedish counties were included. Silver-enhanced in situ hybridisation (SISH) was used for detection of HER2 gene amplification and protein expression was assessed by immunohistochemistry (IHC) in tissue microarrays. HER2 positivity was defined as amplified HER2 gene and/or HER2 3+ by IHC. HER2 status in relation to new ipsilateral events (IBE) and Invasive Breast Cancer Recurrences, local or distant (IBCR) was assessed by Kaplan-Meier survival analyses and Cox proportional hazards regression models. Results: Primary DCIS was screening-detected in 75.5 % of cases. Breast conserving surgery (BCS) was performed in 78.6 % of whom 44.0 % received postoperative radiotherapy. No patients received adjuvant endocrine-or chemotherapy. The majority of DCIS could be HER2 classified (N = 420 (91.7 %)); 132 HER2 positive (31 %) and 288 HER2 negative (69 %)). HER2 positivity was related to large tumor size (P = 0.002), high grade (P &lt; 0.001) and ER-and PR negativity (P &lt; 0.001 for both). During follow-up (mean 184 months), 106 IBCRs and 105 IBEs were identified among all 458 cases corresponding to 54 in situ and 51 invasive recurrences. Eighteen women died from breast cancer and another 114 had died from other causes. The risk of IBCR was statistically significantly lower subsequent to a HER2 positive DCIS compared to a HER2 negative DCIS, (Log-Rank P = 0.03, (HR) 0.60 (95 % CI 0.38-0.94)). Remarkably, the curves did not separate until after 10 years. In ER-stratified analyses, HER2 positive DCIS was associated with lower risk of IBCR among women with ER negative DCIS (Log-Rank P = 0.003), but not for women with ER positive DCIS. Conclusions: Improved prognostic tools for DCIS patients are warranted to tailor adjuvant therapy. Here, we demonstrate that HER2 positive disease in the primary DCIS is associated with lower risk of recurrent invasive breast cancer.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Ductal carcinoma in situ (DCIS)
HER2
Prognostic marker
Breast cancer

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