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A study of docetaxel weekly or every three weeks in combination with carboplatin as first line chemotherapy in epithelial ovarian cancer : Hematological and non-hematological toxicity profiles

Sorbe, Bengt (författare)
Region Örebro län,Dept Oncol, Örebro University Hospital, Örebro, Sweden
Graflund, Marianne (författare)
Dept Oncol, Örebro University Hospital, Örebro, Sweden
Nygren, Lisa (författare)
Dept Oncol, Örebro University Hospital, Örebro, Sweden
visa fler...
Horvath, Gyorgy (författare)
Dept Oncol, Sahlgrenska Univ Hosp, Gothenburg, Sweden
visa färre...
 (creator_code:org_t)
2013
2013
Engelska.
Ingår i: Oncology Letters. - 1792-1074 .- 1792-1082. ; 5:4, s. 1140-1148
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The purpose of this study was to compare the toxicity profiles of docetaxel administered on a weekly schedule and the standard three-week schedule in the treatment of advanced primary ovarian carcinoma. Eligible patients were treated with intravenous docetaxel (30 mg/m(2)) on days 1, 8 and 15, and carboplatin (AUC 5) on day 1 or with docetaxel (75 mg/m(2)) and carboplatin (AUC 5) on day 1; Q21 days for 6 cycles. This study was a pooled study of two primary phase II studies. A total of 108 patients received the weekly schedule and 59 patients received the three-week schedule. All patients were evaluated for toxicity. The overall response rate was 79% and the biochemical response 93% for the weekly schedule. The median overall survival rate was 35.3 months. Neutropenia was significantly more common (ANOVA; p<0.0001) in the three-week group than in the weekly group during all six courses of chemotherapy. Fever and infections were also more common in this group. Thrombocytopenia and anemia were slightly more common in the weekly group. Fatigue, epiphora, nail changes and taste disturbances were specific side-effects following weekly docetaxel. Peripheral sensory neuropathy (grade 1-2) increased with every cycle of treatment, but in a similar manner in the two groups. Grade 3-4 neuropathy was not recorded. Oral mucositis and myalgia were two side-effects associated with the three-week schedule. Nausea and vomiting, diarrhea and dyspnea were a limited problem in both groups. Cardiac toxicity was rare and did not differ between the two docetaxel schedules. The weekly administration was favored due to the lower rates of neutropenia, fever, infections, oral mucositis and myalgia. However, epiphora and nail changes were specific side-effects of the weekly treatment. Both regimens appeared to be rather well tolerated with similar compliance (66 and 70%) with regard to completion of the planned six courses of chemotherapy.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

ovarian cancer
docetaxel
carboplatin
weekly administration
3-week administration
hematological toxicity
non-hematological toxicity

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Av författaren/redakt...
Sorbe, Bengt
Graflund, Marian ...
Nygren, Lisa
Horvath, Gyorgy
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Cancer och onkol ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
Artiklar i publikationen
Oncology Letters
Av lärosätet
Örebro universitet

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