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Sökning: onr:"swepub:oai:DiVA.org:oru-57319" > Ghrelin is a progno...

Ghrelin is a prognostic marker and a potential therapeutic target in breast cancer

Grönberg, Malin, (författare)
Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden
Ahlin, Cecilia, (författare)
Region Örebro län, Department of Oncology, Örebro University Hospital, Örebro, Sweden
Naeser, Ylva, (författare)
Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden
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Janson, Eva Tiensuu, (författare)
Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden
Holmberg, Lars, (författare)
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom
Fjällskog, Marie-Louise, (författare)
Department of Medical Sciences, Section of Endocrine Oncology, Uppsala University, Uppsala, Sweden
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Region Örebro län (creator_code:org_t)
2017
Engelska.
Ingår i: PLoS ONE. - 1932-6203. ; 12:4
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  • Ghrelin and obestatin are gastrointestinal peptides, encoded by the same preproghrelin gene. Both are expressed in breast cancer tissue and ghrelin has been implicated in breast cancer tumorigenesis. Despite recent advances in breast cancer management the need for new prognostic markers and potential therapeutic targets in breast cancer remains high. We studied the prognostic impact of ghrelin and obestatin in women with node negative breast cancer. Within a cohort of women with breast cancer with tumor size ≤ 50 mm, no lymph node metastases and no initiation of adjuvant chemotherapy, 190 women were identified who died from breast cancer and randomly selected 190 women alive at the corresponding time as controls. Tumor tissues were immunostained with antibodies versus the peptides. Ghrelin expression was associated with better breast cancer specific survival in univariate analyses (OR 0.55, 95% CI 0.36-0.84) and in multivariate models, adjusted for endocrine treatment and age (OR 0.57, 95% CI 0.36-0.89). Obestatin expression was non-informative (OR 1.2, 95% CI 0.60-2.46). Ghrelin expression is independent prognostic factor for breast cancer death in node negative patients-halving the risk for dying of breast cancer. Our data implies that ghrelin could be a potential therapeutic target in breast cancer treatment.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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