SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-61042"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-61042" > Histological improv...

Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis : A cohort study

Borssén, Åsa D., (författare)
Department of Public Health and Clinical Medicine, Umeå University, Norrlands Universitetssjukhus, Umeå, Sweden
Palmqvist, Richard, (författare)
Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden
Kechagias, Stergios, (författare)
Department of Gastroenterology and Hepatology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
visa fler...
Marschall, Hanns-Ulrich, (författare)
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Bergquist, Annika, (författare)
Department of Medicine, Section of Hepatology and Gastroenterology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Rorsman, Fredrik, (författare)
Department of Medical Sciences, Section of Gastroenterology and Hepatology, Uppsala University, Uppsala, Sweden
Weiland, Ola, (författare)
Division of Infectious Diseases, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Verbaan, Hans, (författare)
Department of Clinical Sciences, Lund University, University Hospital Skåne, Malmö, Sweden
Nyhlin, Nils, 1971- (författare)
Örebro universitet, Institutionen för medicinska vetenskaper, Region Örebro län, Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden
Nilsson, Emma, (författare)
Department of Clinical Sciences, Lund University, University Hospital Skåne, Malmö, Sweden
Werner, Marten, (författare)
Department of Public Health and Clinical Medicine, Umeå University, Norrlands Universitetssjukhus, Umeå, Sweden
visa färre...
2017
Engelska.
Ingår i: Medicine (Baltimore, Md.). - Lippincott Williams & Wilkins. - 0025-7974 .- 1536-5964. ; 96:34
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • <p>Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that if left untreated may lead to the development of cirrhosis. Previous studies on AIH patients have suggested that fibrosis and even cirrhosis can be reversed by medical treatment. The aim of this study was to evaluate the efficacy of medical treatment for protection of developing fibrosis and cirrhosis.</p><p>A total of 258 liver biopsies from 101 patients (72 women, 29 men) were analyzed by a single pathologist and classified according to the Ishak grading (inflammation) and staging (fibrosis) system. Liver histology was stratified according to the temporal changes of fibrosis stage (increased, decreased, or stable), and groups were compared.</p><p>Complete or partial response to medical treatment was 94.9%. Reduction of fibrosis stage from the first to the last biopsy was seen in 63 patients (62.4%). We found an association between a reduction in the fibrosis stage and continuous glucocorticoid medication, as well as lowered scores of inflammation at last biopsy. Twenty-one patients had cirrhosis (Ishak stage 6) at least in one of the previous biopsies, but only 5 patients at the last biopsy.</p><p>Histological improvement is common in AIH patients that respond to medical treatment, and a reduction or stabilization of fibrosis stage occurs in about 2/3 of such patients.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

autoimmune hepatitis
autoimmune liver disease
cirrhosis
fibrosis
inflammation

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy