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Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

O'Gorman, A., (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland; Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin (UCD) Belfield, Dublin, Ireland
Suvitaival, T., (författare)
Steno Diabetes Center, Gentofte, Denmark
Ahonen, L., (författare)
Steno Diabetes Center, Gentofte, Denmark
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Cannon, M., (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland
Zammit, S., (författare)
Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK; Centre for Academic Mental Health, School of Social & Community Medicine, University of Bristol, Bristol, UK
Lewis, G., (författare)
Division of Psychiatry, University College London, London, UK
Roche, H. M., (författare)
Nutrigenomics Research Group, UCD Conway Institute/UCD Institute of Food & Health, School of Public Health, Physiotherapy & Sports Science, University College Dublin (UCD) Belfield, Dublin, Ireland
Mattila, I., (författare)
Steno Diabetes Center, Gentofte, Denmark
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet, Institutionen för naturvetenskap och teknik, Steno Diabetes Center, Gentofte, Denmark, Department of Chemistry
Oresic, Matej, 1967- (författare)
Örebro universitet, Institutionen för medicinska vetenskaper, Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Turku, Finland; Åbo Akademi University, Turku, Finland
Brennan, L., (författare)
Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin (UCD) Belfield, Dublin, Ireland
Cotter, D. R., (författare)
Department of Psychiatry, Beaumont Hospital, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland
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2017
Engelska.
Ingår i: Translational Psychiatry. - Nature Publishing Group. - 2158-3188 .- 2158-3188. ; 7
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC). Overall, 179 lipids were identified at age 11, with 32 found to be significantly altered between the control and PD groups. Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18: 1), LPC(18: 2), LPC(20: 3); phosphatidlycholines (PCs) PC(32: 2; PC(34: 2), PC(36: 4), PC(0-34-3) and sphingomyelin (SM) SM(d18: 1/24: 0)), all of which were elevated in the PD group. At age 18, 23 lipids were significantly different between the control and PD groups, although none remained significant following correction for multiple comparisons. In conclusion, the findings indicate that the lipidome is altered in the blood during childhood, long before the development of psychotic disorder. LPCs in particular are elevated in those who develop PD, indicating inflammatory abnormalities and altered phospholipid metabolism. These findings were not found at age 18, suggesting there may be ongoing alterations in the pathophysiological processes from prodrome to onset of PD.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

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