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Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs

Leskinen, Tuija, (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Rinnankoski-Tuikka, Rita, (författare)
Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland
Rintala, Mirva, (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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Seppänen-Laakso, Tuulikki, (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Pöllänen, Eija, (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Alen, Markku, (författare)
Department of Medical Rehabilitation, Oulu University Hospital, Oulu, Finland
Sipilä, Sarianna, (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Kaprio, Jaakko, (författare)
Department of Public Health and Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland
Kovanen, Vuokko, (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Rahkila, Paavo, (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Oresic, Matej, 1967- (författare)
Örebro universitet, Institutionen för medicinska vetenskaper, VTT Technical Research Centre of Finland, Espoo, Finland
Kainulainen, Heikki, (författare)
Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland
Kujala, Urho M., (författare)
Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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2010
Engelska.
Ingår i: PLoS ONE. - Public Library of Science. - 1932-6203 .- 1932-6203. ; 5:9
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>High physical activity/aerobic fitness predicts low morbidity and mortality. Our aim was to identify the most up-regulated gene sets related to long-term physical activity vs. inactivity in skeletal muscle and adipose tissues and to obtain further information about their link with cardio-metabolic risk factors. We studied ten same-sex twin pairs (age range 50-74 years) who had been discordant for leisure-time physical activity for 30 years. The examinations included biopsies from m. vastus lateralis and abdominal subcutaneous adipose tissue. RNA was analyzed with the genome-wide Illumina Human WG-6 v3.0 Expression BeadChip. For pathway analysis we used Gene Set Enrichment Analysis utilizing active vs. inactive co-twin gene expression ratios. Our findings showed that among the physically active members of twin pairs, as compared to their inactive co-twins, gene expression in the muscle tissue samples was chronically up-regulated for the central pathways related to energy metabolism, including oxidative phosphorylation, lipid metabolism and supportive metabolic pathways. Up-regulation of these pathways was associated in particular with aerobic fitness and high HDL cholesterol levels. In fat tissue we found physical activity-associated increases in the expression of polyunsaturated fatty acid metabolism and branched-chain amino acid degradation gene sets both of which associated with decreased 'high-risk' ectopic body fat and plasma glucose levels. Consistent with other findings, plasma lipidomics analysis showed up-regulation of the triacylglycerols containing the polyunsaturated fatty acids. Our findings identified skeletal muscle and fat tissue pathways which are associated with the long-term physical activity and reduced cardio-metabolic disease risk, including increased aerobic fitness. In particular, improved skeletal muscle oxidative energy and lipid metabolism as well as changes in adipocyte function and redistribution of body fat are associated with reduced cardio-metabolic risk.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
NATURVETENSKAP  -- Biologiska vetenskaper -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

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