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Sökning: onr:"swepub:oai:DiVA.org:oru-63664" > Peroxisome prolifer...

Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility

Rodriguez-Cuenca, Sergio (författare)
Department of Clinical Biochemistry, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
Carobbio, Stefania (författare)
Department of Clinical Biochemistry, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
Velagapudi, Vidya R. (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
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Barbarroja, Nuria (författare)
VTT Technical Research Centre of Finland, Espoo, Finland; Hospital Virgen de la Victoria, CIBERobn Fisiopatología de la Obesidad y Nutrición, Malaga, Spain
Moreno-Navarrete, Jose Maria (författare)
Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Girona, Spain; CIBERobn Fisiopatología de la Obesidad y Nutrición, Girona, Spain
Tinahones, Francisco Jose (författare)
Hospital Virgen de la Victoria, CIBERobn Fisiopatología de la Obesidad y Nutrición, Malaga, Spain
Fernandez-Real, Jose Manuel (författare)
Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Girona, CIBERobn Fisiopatología de la Obesidad y Nutrición, Girona, Spain
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
Vidal-Puig, Antonio (författare)
Department of Clinical Biochemistry, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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 (creator_code:org_t)
American Society for Microbiology, 2012
2012
Engelska.
Ingår i: Molecular and Cellular Biology. - : American Society for Microbiology. - 0270-7306 .- 1098-5549. ; 32:8, s. 1555-1565
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Optimal lipid storage and mobilization are essential for efficient adipose tissue. Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) regulates adipocyte differentiation and lipid deposition, but its role in lipolysis and dysregulation in obesity is not well defined. This investigation aimed to understand the molecular impact of dysfunctional PPARγ on the lipolytic axis and to explore whether these defects are also confirmed in common forms of human obesity. For this purpose, we used the P465L PPARγ mouse as a model of dysfunctional PPARγ that recapitulates the human pparγ mutation (P467L). We demonstrated that defective PPARγ impairs catecholamine-induced lipolysis. This abnormal lipolytic response is exacerbated by a state of positive energy balance in leptin-deficient ob/ob mice. We identified the protein kinase A (PKA) network as a PPARγ-dependent regulatory node of the lipolytic response. Specifically, defective PPARγ is associated with decreased basal expression of prkaca (PKAcatα) and d-akap1, the lipase genes Pnplaz (ATGL) and Lipe (HSL), and lipid droplet protein genes fsp27 and adrp in vivo and in vitro. Our data indicate that PPARγ is required for activation of the lipolytic regulatory network, dysregulation of which is an important feature of obesity-induced insulin resistance in humans.

Ämnesord

NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
NATURVETENSKAP  -- Biologiska vetenskaper -- Cellbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
NATURVETENSKAP  -- Biologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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