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Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences : Evidence From the Avon Longitudinal Study of Parents and Children

Madrid-Gambin, Francisco (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Focking, Melanie (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Sabherwal, Sophie (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
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Heurich, Meike (författare)
School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom
English, Jane A. (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
O'Gorman, Aoife (författare)
Institute of Food and Health, UCD School of Agriculture and Food Science, Dublin, Ireland
Suvitaival, Tommi (författare)
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Ahonen, Linda (författare)
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Cannon, Mary (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Lewis, Glyn (författare)
Faculty of Brain Sciences, Division of Psychiatry, University College London, London, United Kingdom
Mattila, Ismo (författare)
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Scaife, Caitriona (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Madden, Sean (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Chemistry
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
Zammit, Stanley (författare)
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom; Centre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, United Kingdom
Cagney, Gerard (författare)
Conway Institute, UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
Cotter, David R. (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Brennan, Lorraine (författare)
Institute of Food and Health, UCD School of Agriculture and Food Science, Dublin, Ireland
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 (creator_code:org_t)
Elsevier, 2019
2019
Engelska.
Ingår i: ; 86:1, s. 25-34
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes. The current study investigated early lipidomic and coagulation pathway protein signatures of later PEs in subjects from the Avon Longitudinal Study of Parents and Children cohort.METHODS: Plasma of 115 children (12 years of age) who were first identified as experiencing PEs at 18 years of age (48 cases and 67 controls) were assessed through integrated and targeted lipidomics and semitargeted proteomics approaches. We assessed the lipids, lysophosphatidylcholines (n = 11) and phosphatidylcholines (n = 61), and the protein members of the coagulation pathway (n = 22) and integrated these data with complement pathway protein data already available on these subjects.RESULTS: Twelve phosphatidylcholines, four lysophosphatidylcholines, and the coagulation protein plasminogen were altered between the control and PEs groups after correction for multiple comparisons. Lipidomic and proteomic datasets were integrated into a multivariate network displaying a strong relationship between most lipids that were significantly associated with PEs and plasminogen. Finally, an unsupervised clustering approach identified four different clusters, with one of the clusters presenting the highest case-control ratio (p < .01) and associated with a higher concentration of smaller low-density lipoprotein cholesterol particles.CONCLUSIONS: Our findings indicate that the lipidome and proteome of subjects who report PEs at 18 years of age are already altered at 12 years of age, indicating that metabolic dysregulation may contribute to an early vulnerability to PEs and suggesting crosstalk between these lysophosphatidylcholines, phosphatidylcholines, and coagulation and complement proteins.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

ALSPAC
Early life
Integration
Lipidomics
Proteomics
Psychotic episode

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