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Sökning: onr:"swepub:oai:DiVA.org:oru-81711" > Perinatal and antib...

Perinatal and antibiotic exposures and the risk of developing childhood-onset inflammatory bowel disease : A nested case-control study based on a population-based birth cohort

Canova, C. (författare)
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy
Ludvigsson, Jonas F., 1969- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, United States
Di Domenicantonio, R. (författare)
Department of Epidemiology, Lazio Regional Health Service, ASL Rome, Italy
visa fler...
Zanier, L. (författare)
Epidemiological Service, Health Directorate, Udine, Italy
Amidei, C. B. (författare)
Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy
Zingone, F. (författare)
Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, Padua, Italy
Canova, C (författare)
Ludvigsson, JF (författare)
Karolinska Institutet
Zanier, L (författare)
Zingone, F (författare)
Amidei, CB (författare)
Di Domenicantonio, R (författare)
visa färre...
 (creator_code:org_t)
MDPI, 2020
2020
Engelska.
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:7
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The role of early-life environmental exposures on Inflammatory Bowel Disease (IBD) onset remains unclear. We aimed to quantify the impact of perinatal conditions and antibiotic use in the first 6 and 12 months of life, on the risk of childhood-onset IBD, in a birth cohort of the region Friuli-Venezia Giulia (Italy). A nested case-control design on a longitudinal cohort of 213,515 newborns was adopted. Conditional binomial regression models were used to estimate Odds Ratios (OR) with 95% confidence intervals (CI) for all analyzed risk factors. We identified 164 individuals with IBD onset before the age of 18 years and 1640 controls. None of the considered perinatal conditions were associated with IBD. Analyses on antibiotic exposure were based on 70 cases and 700 controls. Risks were significantly higher for children with ≥4 antibiotic prescriptions in the first 6 and 12 months of life (OR = 6.34; 95%CI 1.68–24.02 and OR = 2.91; 95%CI 1.31–6.45, respectively). This association was present only among patients with Crohn’s disease and those with earlier IBD onset. We found that perinatal characteristics were not associated to IBD, while the frequent use of antibiotics during the first year of life was associated to an increased risk of developing subsequent childhood-onset IBD.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Birth cohort study
Crohn disease
Epidemiology
Pediatric IBD
Perinatal and postnatal exposure
Pharmacoepidemiology
Real-world data
Record linkage
Ulcerative colitis
VEO-IBD
antibiotic agent
antibiotics
child health
digestive system disorder
disease incidence
drug prescribing
health risk
risk assessment
risk factor
adult
Article
birth
case control study
child
childhood
cohort analysis
confidence interval
controlled study
female
human
inflammatory bowel disease
Italy
longitudinal study
major clinical study
male
newborn
odds ratio
onset age
perinatal period
population research
prescription
retrospective study
Friuli-Venezia Giulia

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