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Sökning: onr:"swepub:oai:DiVA.org:oru-83805" > Urinary Phthalate B...

Urinary Phthalate Biomarker Concentrations and Postmenopausal Breast Cancer Risk

Reeves, Katherine W. (författare)
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
Díaz Santana, Mary (författare)
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
Manson, JoAnn E. (författare)
Department of Medicine, Harvard T.H. Chan School of Public Health, Boston, USA
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Hankinson, Susan E. (författare)
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
Zoeller, R. Thomas, 1952- (författare)
Department of Biology, University of Massachusetts, Amherst, USA
Bigelow, Carol (författare)
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
Sturgeon, Susan R. (författare)
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
Spiegelman, Donna (författare)
Department of Medicine, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Biostatistics, Yale School of Public Health, New Haven, USA
Tinker, Lesley (författare)
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
Luo, Juhua (författare)
Department of Epidemiology and Biostatistics, Indiana University, Bloomington, USA
Chen, Bertha (författare)
Department of Ob/Gyn, Stanford University School of Medicine, Stanford, USA
Meliker, Jaymie (författare)
Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, USA
Bonner, Matthew R. (författare)
Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, USA
Cote, Michele L. (författare)
Department of Oncology, Wayne State University, Detroit, USA; Karmanos Cancer Institute, Detroit, USA
Cheng, Ting-Yuan David (författare)
Departments of Epidemiology and Public Health and Health Professions, University of Florida, Gainesville, USA
Calafat, Antonia M. (författare)
Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, USA
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Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA Department of Medicine, Harvard TH. Chan School of Public Health, Boston, USA (creator_code:org_t)
Oxford University Press, 2019
2019
Engelska.
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 111:10, s. 1059-1067
  • Tidskriftsartikel (refereegranskat)
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  • BACKGROUND: Growing laboratory and animal model evidence supports the potentially carcinogenic effects of some phthalates, chemicals used as plasticizers in a wide variety of consumer products, including cosmetics, medications, and vinyl flooring. However, prospective data on whether phthalates are associated with human breast cancer risk are lacking.METHODS: We conducted a nested case-control study within the Women's Health Initiative (WHI) prospective cohort (n = 419 invasive case subjects and 838 control subjects). Control subjects were matched 2:1 to case subjects on age, enrollment date, follow-up time, and WHI study group. We quantified 13 phthalate metabolites and creatinine in two or three urine samples per participant over one to three years. Multivariable conditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer risk associated with each phthalate biomarker up to 19 years of follow-up.RESULTS: Overall, we did not observe statistically significant positive associations between phthalate biomarkers and breast cancer risk in multivariable analyses (eg, 4th vs 1st quartile of diethylhexyl phthalate, OR = 1.03, 95% CI = 0.91 to 1.17). Results were generally similar in analyses restricted to disease subtypes, to nonusers of postmenopausal hormone therapy, stratified by body mass index, or to case subjects diagnosed within three, five, or ten years.CONCLUSIONS: In the first prospective analysis of phthalates and postmenopausal breast cancer, phthalate biomarker concentrations did not result in an increased risk of developing invasive breast cancer.

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