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Genetic and shared environmental risk factors do not lead to eosinophil activation in healthy twins of IBD patients

Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology
Lundström, Maria Ling (författare)
Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden
Lampinen, Maria (författare)
Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden
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Schoultz, Ida, 1979- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Bodin, Lennart, 1941- (författare)
Örebro universitet,Handelshögskolan vid Örebro Universitet,Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
Carlson, Marie (författare)
Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden
Ling Lundström, M (författare)
Lampinen, M (författare)
Halfvarson, J (författare)
Carlson, M (författare)
Schoultz, I (författare)
Bodin, L (författare)
Karolinska Institutet
Lundstrom, ML (författare)
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 (creator_code:org_t)
Taylor & Francis, 2020
2020
Engelska.
Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:10, s. 1163-1170
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective: To examine the role of eosinophils in the pre-diagnostic phase of inflammatory bowel disease (IBD), we studied the influence of genetic and shared environmental risk factors in a twin cohort of IBD.Material and methods: We analysed eosinophil derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in faecal samples from twin pairs with Crohn's disease (n = 37) or ulcerative colitis (n = 21) and from external healthy controls (n = 44). Eosinophils stained with eosinophil peroxidase (EPO) were quantified in rectal biopsies. Ratios with 95% confidence intervals were calculated.Results: Twins with Crohn' disease displayed higher levels of EDN (Ratio = 2.98, 1.65-5.37) and ECP (Ratio 1.83, 1.24-2.70) than their healthy siblings. Levels did not differ between healthy twin-siblings and external controls (EDN, Ratio = 1.52, 0.79-2.94 and ECP, Ratio = 0.93, 0.56-1.54). Higher levels of EDN (Ratio = 2.43, 1.13-5.24) and ECP (Ratio = 1.53, 0.92-2.53) were observed among twins with ulcerative colitis vs their healthy siblings. Levels did not differ between healthy twin-siblings and external controls (EDN, Ratio = 1.08, 0.51-2.25 and ECP, Ratio = 1.29, 0.74-2.26). Using intra-class correlation coefficient (ICC), we found no agreement in levels of EDN or ECP in discordant pairs, except for ECP in monozygotic Crohn's disease pairs (ICC = 0.63). In contrast, agreement was observed in monozygotic pairs concordant for Crohn's disease (EDN, ICC = 0.67 and ECP, ICC = 0.66). The number of eosinophils in rectum was increased in twins with ulcerative colitis vs their healthy sibling (Ratio = 2.22, 1.50-3.27).Conclusions: Activation of eosinophils in IBD seems to be a consequence of inflammation rather than an effect of genetic and shared environmental risk factors alone.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Inflammatory bowel disease
eosinophils
twins
faecal markers

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