William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England.
Warren, Helen R. (författare)
William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England.
Rose, Lynda M. (författare)
Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
Jackson, Anne U. (författare)
Univ Michigan, Dept Biostat, Ann Arbor, MI USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI USA.
Nelson, Christopher P. (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Huffman, Jennifer E. (författare)
Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Gandin, Ilaria (författare)
Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
Harris, Sarah E. (författare)
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, Med Genet Sect, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Zemunik, Tatijana (författare)
London North West Healthcare NHS Trust, Dept Med Biol, Fac Med, Southall, Middx, England.
Lu, Yingchang (författare)
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA.
Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy.
Barnes, Michael R. (författare)
William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England.
Busselton Populat Med Res Inst, Nedlands, WA, Australia.;PathWest Lab Med Western Australia, Nedlands, WA, Australia.;Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA, Australia.
Univ Michigan, Dept Biostat, Ann Arbor, MI USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI USA.
Bottinger, Erwin P. (författare)
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA.
Braund, Peter S. (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Brown, Morris (författare)
William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England.
Brumat, Marco (författare)
Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ, Ctr Mol Med, Solna, Sweden.
Harris, Tamara B. (författare)
NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
Hofman, Albert (författare)
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
Holliday, Elizabeth G. (författare)
Hunter Med Res Inst, New Lambton, NSW, Australia.
Hui, Jennie (författare)
Busselton Populat Med Res Inst, Nedlands, WA, Australia.;PathWest Lab Med Western Australia, Nedlands, WA, Australia.;Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Nedlands, WA, Australia.
Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Dept Clin Physiol, Fac Med & Life Sci, Tampere, Finland.
Kathiresan, Sekar (författare)
Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy.
Oldehinkel, Albertine J. (författare)
Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
Oostra, Ben A. (författare)
Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands.
Org, Elin (författare)
Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
Padmanabhan, Sandosh (författare)
Univ Edinburgh, Generat Scotland, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.;Univ Glasgow, British Heart Fdn, Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci,Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.;Univ Glasgow, Inst Cardiovasc & Med Sci, Fac Med, Glasgow, Lanark, Scotland.
Palotie, Aarno (författare)
Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
Pare, Guillaume (författare)
McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada.
Univ Glasgow, Inst Cardiovasc & Med Sci, Fac Med, Glasgow, Lanark, Scotland.
Sundstrom, Johan(författare)
Swertz, Morris (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
Taylor, Kent D. (författare)
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles BioMed Res Inst, Torrance, CA USA.;Harbor UCLA Med Ctr, Div Genet Outcomes, Dept Pediat, Torrance, CA USA.
Thom, Simon (författare)
Imperial Coll London, Int Ctr Circulatory Hlth, London, England.
Vrije Univ, VU Univ Med Ctr, EMGO Inst, Dept Biol Psychol, Amsterdam, Netherlands.
Wright, Alan F. (författare)
Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Yao, Jie (författare)
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA USA.
Theriault, Sebastien (författare)
McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada.
Conen, David (författare)
McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
Attia, John (författare)
Hunter Med Res Inst, New Lambton, NSW, Australia.;Univ Newcastle, Fac Hlth, Callaghan, NSW, Australia.;John Hunter Hosp, New Lambton, NSW, Australia.
Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Inst Metab Sci, Cambridge, England.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY USA.
Polasek, Ozren (författare)
Univ Split, Dept Publ Hlth, Fac Med, Split, Croatia.
Broad Inst Harvard & MIT, Cambridge, MA USA.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
Vitart, Veronique (författare)
Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Samani, Nilesh J. (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
Tuomilehto, Jaakko (författare)
Dasman Diabet Inst, Kuwait, Kuwait.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.;Danube Univ Krems, Dept Neurosci & Prevent Med, Krems An Der Donau, Austria. Univ Manchester, Div Cardiovasc Sci, Manchester, Lancs, England.
Gyllensten, Ulf (författare)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland.
van Duijn, Cornelia M. (författare)
Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands.
Gudnason, Vilmundur (författare)
Icelandic Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
Psaty, Bruce M. (författare)
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Kaiser Permanent, Washington Hlth Res Inst, Seattle, WA USA.
Peters, Annette (författare)
Helmholtz Zentrum Munchen, Inst Epidemiol 2, Munich, Germany.
Rettig, Rainer (författare)
Univ Med Greifswald, Inst Physiol, Karlsburg, Germany.
James, Alan (författare)
Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA, Australia.;Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep, Nedlands, WA, Australia.
Jukema, J. Wouter (författare)
Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.
Strachan, David P. (författare)
St Georges Univ London, Populat Hlth Res Inst, London, England.
Palmas, Walter (författare)
Columbia Univ, Dept Med, Med Ctr, New York, NY USA.
Metspalu, Andres (författare)
Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
Ingelsson, Erik (författare)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Boomsma, Dorret I. (författare)
Vrije Univ, VU Univ Med Ctr, EMGO Inst, Dept Biol Psychol, Amsterdam, Netherlands.
Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.
Newton-Cheh, Christopher (författare)
Broad Inst Harvard & MIT, Cambridge, MA USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Munroe, Patricia B. (författare)
William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England.
NHLBI, Populat Sci Branch, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
Tobin, Martin D.(författare)
Snieder, Harold (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
Caulfield, Mark J. (författare)
William Harvey Res Inst, Clin Pharmacol, London, England.;Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, Barts & London Sch Med & Dent, London, England.
Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden.;Karolinska Univ, Ctr Mol Med, Solna, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, Stockholm, Sweden.
Nguyen, Quang Tri(författare)
Johansson, Åsa (författare)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)