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RADIATION-INDUCED C...
RADIATION-INDUCED CHANGES IN LEVELS OF SELECTED PROTEINS IN PERIPHERAL BLOOD SERUM OF BREAST CANCER PATIENTS AS A POTENTIAL TRIAGE BIODOSIMETER FOR LARGE-SCALE RADIOLOGICAL EMERGENCIES
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- Deperas-Kaminska, Marta (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Institute of Mother and Child, Poland
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- Bajinskis, Ainars (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Latvia, Latvia
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Marczyk, Michal (författare)
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Polanska, Joanna (författare)
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- Wersäll, Peter (författare)
- Karolinska Institutet
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Lidbrink, Elisabet (författare)
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Ainsbury, Elizabeth A. (författare)
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Guipaud, Oliver (författare)
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Benderitter, Marc (författare)
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- Haghdoost, Siamak (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Wojcik, Andrzej (författare)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Jan Kochanowski University, Poland
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(creator_code:org_t)
- 2014
- 2014
- Engelska.
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Ingår i: Health Physics. - 0017-9078 .- 1538-5159. ; 107:6, s. 555-563
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- The threat of a large scale radiological emergency, where thousands of people may require fast biological dosimetry for the purpose of triage, makes it necessary to search for new, high throughput biological dosimeters. The authors tested an assay based on the quantitative analysis of selected proteins in peripheral blood serum. They were particularly interested in testing proteins that are specific to irradiation of skin, as these can be used in cases of partial body exposure. Candidate proteins were identified in an earlier study with mice, where skin of the animals was exposed to different doses of radiation and global expression of serum proteins was analyzed. Eight proteins were found, the expression of which showed a consistent dose-response relationship. Human analogues of these proteins were identified, and their expression was measured in peripheral blood serum of 16 breast cancer patients undergoing external beam radiotherapy. The proteins were Apolipoprotein E; Apolipoprotein H; Complement protein 7; Prothrombinase; Pantothenate Kinase 4; Alpha-2-macroglobulin; Fetuin B and Alpha-1-Anti-Chymotrypsin. Measurements were carried out in blood samples collected prior to exposure (control), on the day after one fraction (2 Gy), on the day after five fractions (10 Gy), on the day after 10 fractions (20 Gy), and 1 mo after 23-25 fractions (total dose of 46-50 Gy). Multivariate analysis was carried out, and a multinomial logistic regression model was built. The results indicate that the combined analysis of Apolipoprotein E, Factor X, and Pantothenate Kinase 4 allows discriminating between exposure to 2 Gy and lower and between 10 Gy and higher. The discrimination is possible up to 1 mo after exposure.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- accidents
- handling
- biological indicators
- emergency planning
- radiation dose
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Till lärosätets databas
- Av författaren/redakt...
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Deperas-Kaminska ...
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Bajinskis, Ainar ...
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Marczyk, Michal
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Polanska, Joanna
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Wersäll, Peter
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Lidbrink, Elisab ...
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visa fler...
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Ainsbury, Elizab ...
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Guipaud, Oliver
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Benderitter, Mar ...
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Haghdoost, Siama ...
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Wojcik, Andrzej
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Maskinteknik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Health Physics
- Av lärosätet
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Stockholms universitet
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Karolinska Institutet