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Sökning: onr:"swepub:oai:DiVA.org:su-166193" > A Multi-Cohort Stud...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005119naa a2200829 4500
001oai:DiVA.org:su-166193
003SwePub
008190320s2017 | |||||||||||000 ||eng|
024a urn:nbn:se:su:diva-1661932 urn
024a https://doi.org/10.3233/JAD-1610972 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Khan, Wasim4 aut
2451 0a A Multi-Cohort Study of ApoE epsilon 4 and Amyloid-beta Effects on the Hippocampus in Alzheimer's Disease
264 1c 2017
338 a print2 rdacarrier
520 a The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer's disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), we compared the effect of APOE and amyloid-beta (A beta) on baseline hippocampal volumes in AD patients, mild cognitive impairment (MCI) subjects, and healthy controls. A large sample of healthy adolescents (n = 1,387) was also used to compare hippocampal volumes between APOE groups. Subjects had undergone a magnetic resonance imaging (MRI) scan and APOE genotyping. Hippocampal volumes were processed using FreeSurfer. In the AD and normal aging dataset, hippocampal comparisons were performed in each APOE group and in epsilon 4 carriers with positron emission tomography (PET) A beta who were dichotomized (A beta+/A beta-) using previous cut-offs. We found a linear reduction in hippocampal volumes with epsilon 4 carriers possessing the smallest volumes, epsilon 3 carriers possessing intermediate volumes, and epsilon 2 carriers possessing the largest volumes. Moreover, AD and MCI epsilon 4 carriers possessed the smallest hippocampal volumes and control epsilon 2 carriers possessed the largest hippocampal volumes. Subjects with both APOE epsilon 4 and A beta positivity had the lowest hippocampal volumes when compared to A beta-epsilon 4 carriers, suggesting a synergistic relationship between APOE epsilon 4 and A beta. However, we found no hippocampal volume differences between APOE groups in healthy 14-year-old adolescents. Our findings suggest that the strongest neuroanatomic effect of APOE epsilon 4 on the hippocampus is observed in AD and groups most at risk of developing the disease, whereas hippocampi of old and young healthy individuals remain unaffected.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Alzheimer's disease
653 a amyloid
653 a APOE epsilon 4
653 a hippocampus
653 a magnetic resonance imaging
653 a mild cognitive impairment
700a Giampietro, Vincent4 aut
700a Banaschewski, Tobias4 aut
700a Barker, Gareth J.4 aut
700a Bokde, Arun L. W.4 aut
700a Buechel, Christian4 aut
700a Conrod, Patricia4 aut
700a Flor, Herta4 aut
700a Frouin, Vincent4 aut
700a Garavan, Hugh4 aut
700a Gowland, Penny4 aut
700a Heinz, Anreas4 aut
700a Ittermann, Bernd4 aut
700a Lemaître, Hervé4 aut
700a Nees, Frauke4 aut
700a Paus, Tomas4 aut
700a Pausova, Zdenka4 aut
700a Rietschel, Marcella4 aut
700a Smolka, Michael N.4 aut
700a Ströhle, Andreas4 aut
700a Gallinat, Jeurgen4 aut
700a Vellas, Bruno4 aut
700a Soininen, Hilkka4 aut
700a Kloszewska, Iwona4 aut
700a Tsolaki, Magda4 aut
700a Mecocci, Patrizia4 aut
700a Spenger, Christian4 aut
700a Villemagne, Victor L.4 aut
700a Masters, Colin L.4 aut
700a Muehlboeck, J-Sebastian4 aut
700a Bäckman, Larsu Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700a Fratiglioni, Laurau Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700a Kalpouzos, Grégoriau Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700a Wahlund, Lars-Olof4 aut
700a Schumann, Gunther4 aut
700a Lovestone, Simon4 aut
700a Williams, Steven C. R.4 aut
700a Westman, Eric4 aut
700a Simmons, Andrew4 aut
710a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org
773t Journal of Alzheimer's Diseaseg 56:3, s. 1159-1174q 56:3<1159-1174x 1387-2877x 1875-8908
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-166193x lärosäteslänky Till lärosätets (su) databas
8564 8u https://doi.org/10.3233/JAD-161097

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