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Sökning: onr:"swepub:oai:DiVA.org:su-79795" > The interface of pr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004496naa a2200817 4500
001oai:DiVA.org:su-79795
003SwePub
008120911s2012 | |||||||||||000 ||eng|
024a urn:nbn:se:su:diva-797952 urn
024a https://doi.org/10.1002/pro.20712 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
100a Liberles, David A.4 aut
2451 0a The interface of protein structure, protein biophysics, and molecular evolution
264 1c 2012
338 a electronic2 rdacarrier
500 a AuthorCount:33;
506 a gratis
520 a The interface of protein structural biology, protein biophysics, molecular evolution, and molecular population genetics forms the foundations for a mechanistic understanding of many aspects of protein biochemistry. Current efforts in interdisciplinary protein modeling are in their infancy and the state-of-the art of such models is described. Beyond the relationship between amino acid substitution and static protein structure, protein function, and corresponding organismal fitness, other considerations are also discussed. More complex mutational processes such as insertion and deletion and domain rearrangements and even circular permutations should be evaluated. The role of intrinsically disordered proteins is still controversial, but may be increasingly important to consider. Protein geometry and protein dynamics as a deviation from static considerations of protein structure are also important. Protein expression level is known to be a major determinant of evolutionary rate and several considerations including selection at the mRNA level and the role of interaction specificity are discussed. Lastly, the relationship between modeling and needed high-throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction.
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a NATURVETENSKAPx Biologiska vetenskaperx Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a evolutionary modeling
653 a domain evolution
653 a sequence-structure-function relationships
653 a protein dynamics
653 a protein thermodynamics
653 a gene duplication
653 a protein expression
653 a ancestral sequence reconstruction
700a Teichmann, Sarah A.4 aut
700a Bahar, Ivet4 aut
700a Bastolla, Ugo4 aut
700a Bloom, Jesse4 aut
700a Bornberg-Bauer, Erich4 aut
700a Colwell, Lucy J.4 aut
700a de Koning, A. P. Jason4 aut
700a Dokholyan, Nikolay V.4 aut
700a Echave, Julian4 aut
700a Elofsson, Arneu Stockholms universitet,Institutionen för biokemi och biofysik4 aut0 (Swepub:su)aelof
700a Gerloff, Dietlind L.4 aut
700a Goldstein, Richard A.4 aut
700a Grahnen, Johan A.4 aut
700a Holder, Mark T.4 aut
700a Lakner, Clemens4 aut
700a Lartillot, Nicholas4 aut
700a Lovell, Simon C.4 aut
700a Naylor, Gavin4 aut
700a Perica, Tina4 aut
700a Pollock, David D.4 aut
700a Pupko, Tal4 aut
700a Regan, Lynne4 aut
700a Roger, Andrew4 aut
700a Rubinstein, Nimrod4 aut
700a Shakhnovich, Eugene4 aut
700a Sjoelander, Kimmen4 aut
700a Sunyaev, Shamil4 aut
700a Teufel, Ashley I.4 aut
700a Thorne, Jeffrey L.4 aut
700a Thornton, Joseph W.4 aut
700a Weinreich, Daniel M.4 aut
700a Whelan, Simon4 aut
710a Stockholms universitetb Institutionen för biokemi och biofysik4 org
773t Protein Scienceg 21:6, s. 769-785q 21:6<769-785x 0961-8368x 1469-896X
856u http://su.diva-portal.org/smash/get/diva2:551573/FULLTEXT02.pdf
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795x lärosäteslänky Till lärosätets (su) databas
8564 8u https://doi.org/10.1002/pro.2071

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