Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia.
Arslan, Alan A. (författare)
NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA.;NYU, Sch Med, Dept Environm Med, New York, NY USA.;NYU, Sch Med, Dept Populat Hlth, New York, NY USA.;NYU Langone, Med Ctr, Perlmutter Canc Ctr, New York, NY USA.
Austin, Melissa A. (författare)
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Baris, Dalsu(författare)
Barkauskas, Donald A. (författare)
Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA.
Bassig, Bryan A. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.;Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA. German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Baden Wurttembe, Germany.
Becker, Nikolaus(författare)
Benavente, Yolanda (författare)
Inst Catala Oncol, IDIBELL, Unit Infect & Canc UNIC, Canc Epidemiol Res Programme, Barcelona, Spain.;Ctr Invest Biomed Red Epidemiol Salud Publ CIBERE, Madrid, Spain.
Natl Canc Inst, Canc Prevent Div, Early Detect Res Grp, Bethesda, MD USA.
Van Den Berg, David (författare)
Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA.;Univ So Calif, Norris Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA USA.
Bernstein, Leslie (författare)
Beckman Res Inst City Hope, Dept Canc Etiol, Duarte, CA USA.
Bertrand, Kimberly A. (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
Birmann, Brenda M. (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.
Black, Amanda (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
Boeing, Heiner (författare)
German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany.
Boffetta, Paolo (författare)
Tisch Canc Inst, Icahn Sch Med Mt Sinai, New York, NY USA.
Boutron-Ruault, Marie-Christine (författare)
Univ Paris 11, F-94805 Villejuif, France.;Inst Gustave Roussy, F-94805 Villejuif, France.
Bracci, Paige M. (författare)
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
Brinton, Louise (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China.
Chang, Ellen T. (författare)
Stanford Univ, Sch Med, Div Epidemiol, Dept Hlth Res & Policy, Stanford, CA 94305 USA.;Exponent Inc, Ctr Epidemiol & Computat Biol, Hlth Sci, Menlo Pk, CA USA.
Chang, Gee-Chen (författare)
Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 112, Taiwan.;Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Taichung, Taiwan.
Chang, I-Shou (författare)
Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan.
Chang, Jiang (författare)
Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
Chang-Claude, Jenny(författare)
Chen, Chien-Jen (författare)
Genom Res Ctr, Taipei, Taiwan.
Chen, Chih-Yi (författare)
Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg,Inst Med, Taichung, Taiwan.
Chen, Chu (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
Chen, Chung-Hsing (författare)
Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan.
Chen, Constance (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
Chen, Hongyan (författare)
Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China.
Chen, Kexin (författare)
Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Dept Epidemiol & B, Tianjin, Peoples R China.
Univ British Columbia, Dept Med, Vancouver, BC, Canada.
Conti, David (författare)
Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA.;Univ So Calif, Norris Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA USA.
Cortessis, Victoria K. (författare)
Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA.;Univ So Calif, Norris Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA USA.;Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA.
Cotterchio, Michelle (författare)
Canc Care Ontario, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
Cozen, Wendy (författare)
Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA.;Univ So Calif, Norris Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA USA.
Crouch, Simon (författare)
Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
Crous-Bou, Marta (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
Cussenot, Olivier (författare)
Ctr Rech Pathol Prostat, Paris, France.;Univ Paris 06, ONCOTYPE URO, GRC 5, Paris, France.;Hop Tenon, AP HP, Dept Urol, F-75970 Paris, France.
Natl Cheng Kung Univ, Cheng Kung Univ Med Coll & Hosp, Dept Internal Med, Tainan 701, Taiwan.
Lin, Dongxin (författare)
Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
Lindstrom, Sara (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
Linet, Martha S. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
Link, Brian K.(författare)
Liu, Chenwei (författare)
Natl Canc Inst, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA.
Liu, Jianjun (författare)
Qujing Ctr Dis Control & Prevent, Sanjiangdadao, Qujing, Peoples R China.;Genome Inst Singapore, Human Genet, Singapore, Singapore.
Aichi Canc Res Inst, Div Mol Med, Nagoya, Aichi, Japan.
Maynadie, Marc (författare)
Univ Burgundy, Registre Hemopathies Malignes Cote dOr, EA 4184, Dijon, France.;Dijon Univ Hosp, Dijon, France.
Mckay, James (författare)
Int Agcy Res Canc, F-69372 Lyon, France.
McKean-Cowdin, Roberta (författare)
Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA.
Melbye, Mads (författare)
Statens Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, DK-2300 Copenhagen, Denmark.;Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA. Brown Univ, Dept Epidemiol, Div Biol & Med, Providence, RI 02912 USA.
Seoul St Marys Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.
Tan, Wen (författare)
Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
Tang, Wei (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang 110001, Peoples R China.;SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
Wang, Chaoyu (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
Wang, Chih-Liang (författare)
Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan.
Wang, Jiu-Cun (författare)
Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China.;Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China.
Wang, Junwen (författare)
Univ Hong Kong, Li Ka Shing Fac Med, Ctr Genom Sci, Hong Kong, Peoples R China.;Univ Hong Kong, Li Ka Shing Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China.
Wei, Fusheng (författare)
China Natl Environm Monitoring Ctr, Beijing, Peoples R China.
Weiderpass, Elisabete (författare)
Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.;Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway. Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain.;Canc Registry Norway, Oslo, Norway.;Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland.
Weiner, George J. (författare)
Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA USA.
Weinstein, Stephanie (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
Wentzensen, Nicolas (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
White, Emily (författare)
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Witzig, Thomas E. (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Wolpin, Brian M. (författare)
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
Wong, Maria Pik (författare)
Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Hong Kong, Peoples R China.
Wu, Chen (författare)
Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.;Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
Wu, Guoping (författare)
China Natl Environm Monitoring Ctr, Beijing, Peoples R China.
Wu, Junjie (författare)
Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China.
Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96822 USA. Stanford Univ, Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA.
Yu, Kai (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.
Yuan, Jian-Min (författare)
Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. Georgetown Univ, Med Ctr, Innovat Ctr Biomed Informat, Washington, DC USA. Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA.
Zelenetz, Andrew (författare)
NYU, Sch Med, Dept Environm Med, New York, NY USA.;NYU, Sch Med, Dept Populat Hlth, New York, NY USA.;NYU Langone, Med Ctr, Perlmutter Canc Ctr, New York, NY USA.;Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA.
Zeleniuch-Jacquotte, Anne(författare)
Zhang, Xu-Chao (författare)
Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Prov Key Lab Translat Med Lung Canc, Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China.
Zhang, Yawei (författare)
Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA. German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Baden Wurttembe, Germany.
Zhao, Xueying (författare)
Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China.
Zhao, Zhenhong (författare)
Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China.
Zheng, Hong (författare)
Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Dept Epidemiol & B, Tianjin, Peoples R China.
Zheng, Tongzhang (författare)
Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA. German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Baden Wurttembe, Germany.
Zheng, Wei (författare)
Vanderbilt Univ, Ctr Med, Dept Med, Nashville, TN 37232 USA.;Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN USA.
Zhou, Baosen (författare)
China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang 110001, Peoples R China.
Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)