Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
Webb, Thomas R. (författare)
University of Leicester,Glenfield Hospital,Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.
Erdmann, Jeanette (författare)
German Centre for Cardiovascular Research,University of Lübeck,Univ Lubeck, Inst Cardiogenet, Lubeck, Germany.;DZHK German Res Ctr Cardiovasc Res, Lubeck, Germany.;Univ Heart Ctr Luebeck, Lubeck, Germany.
Stirrups, Kathleen E. (författare)
University of Cambridge,Queen Mary University,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Univ Cambridge, Dept Haematol, Cambridge, England.
Washington University in St. Louis,Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.;Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA.
Masca, Nicholas G. D. (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.
Jansen, Henning (författare)
Technical University of Munich,German Centre for Cardiovascular Research,Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.
Kanoni, Stavroula (författare)
Queen Mary University,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
Nelson, Christopher P. (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.
Ferrario, Paola G. (författare)
German Centre for Cardiovascular Research,University of Lübeck,DZHK German Res Ctr Cardiovasc Res, Lubeck, Germany.;Univ Lubeck, Inst Med Biometrie & Stat, Lubeck, Germany.
Koenig, Inke R. (författare)
DZHK German Res Ctr Cardiovasc Res, Lubeck, Germany.;Univ Lubeck, Inst Med Biometrie & Stat, Lubeck, Germany.
Eicher, John D. (författare)
Framingham Heart Study,NHLBI, Ctr Populat Studies, Framingham Heart Study, Framingham, MA USA.
Johnson, Andrew D. (författare)
NHLBI, Ctr Populat Studies, Framingham Heart Study, Framingham, MA USA.
Hamby, Stephen E. (författare)
Glenfield Hospital,University of Leicester,Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.
Betsholtz, Christer (författare)
Uppsala universitet,Uppsala University,Karolinska Institutet,Vaskulärbiologi,Karolinska Inst, Vasc Biol Unit, Dept Med Biochem & Biophys, Stockholm, Sweden.
Ruusalepp, Arno (författare)
Tartu University Hospital,University of Tartu,Clinical Gene Networks AB,Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, Tartu, Estonia.;Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.
Franzen, Oscar (författare)
Clin Gene Networks AB, Stockholm, Sweden.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.
Schadt, Eric E. (författare)
Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.
Bjoerkegren, Johan L. M. (författare)
Karolinska Inst, Vasc Biol Unit, Dept Med Biochem & Biophys, Stockholm, Sweden.;Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.
University of Wisconsin-Milwaukee,Univ Wisconsin, Sch Publ Hlth, Milwaukee, WI 53201 USA.
Schick, Ursula M. (författare)
Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
Lu, Yingchang (författare)
Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.
Zhang, He (författare)
University of Michigan,Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
Wellcome Trust Centre for Human Genetics,University of Oxford,Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
Farrall, Martin (författare)
Wellcome Trust Centre for Human Genetics,University of Oxford,Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
Peloso, Gina M. (författare)
Broad Institute,Massachusetts General Hospital,Harvard Medical School,Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Won, Hong-Hee (författare)
Harvard Medical School,Massachusetts General Hospital,Broad Institute,Sungkyunkwan University,Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea.
Do, Ron (författare)
Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Ctr Stat Genet, Dept Genet & Genom Sci, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Zena & Michael Weiner Cardiovasc Inst, New York, NY 10029 USA.
van Iperen, Erik (författare)
Acad Med Ctr, Dept Biostat, Amsterdam, Netherlands.
Kruppa, Jochen (författare)
University of Veterinary Medicine Hannover,Univ Vet Med Hannover, Inst Anim Breeding & Genet, Hannover, Germany.
Mahajan, Anubha (författare)
Wellcome Trust Centre for Human Genetics,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
University of Kiel,Christian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
Heilmann, Stefanie (författare)
University of Bonn,Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.
Hengstenberg, Christian (författare)
Technical University of Munich,Washington University in St. Louis,Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA.;Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
Hoffmann, Per (författare)
University of Bonn,University of Basel,Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Div Med Genet, Basel, Switzerland.
Holmen, Oddgeir L. (författare)
Norwegian University of Science and Technology,St. Olav’s University Hospital,Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway.;Trondheim Reg & Univ Hosp, St Olav Hosp, Trondheim, Norway.
Hveem, Kristian (författare)
Norwegian University of Science and Technology,Nord-Trøndelag Health Trust,Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway.;Nord Trondelag Hlth Trust, Levanger Hosp, Dept Med, Levanger, Norway.
Jansson, Jan-Håkan (författare)
Umeå University,Umeå universitet,Medicin,Research Unit Skellefteå
Technical University of Munich,German Centre for Cardiovascular Research,Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.
Kriebel, Jennifer (författare)
Helmholtz Zentrum München,German Center for Diabetes Research,Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.
Laugwitz, Karl L. (författare)
Klinikum rechts der Isar,German Centre for Cardiovascular Research,DZHK, Munich, Germany.;Tech Univ Munich, Klinikum Rechts Isar, Inst Med Klin & Poliklin, Munich, Germany.
Marouli, Eirini (författare)
Queen Mary University,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
Martinelli, Nicola (författare)
University of Verona,Univ Verona, Sect Internal Med, Dept Med, Verona, Italy.
McCarthy, Mark I. (författare)
University of Oxford,Churchill Hospital,Wellcome Trust Centre for Human Genetics,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Biomed Res Ctr, Oxford Natl Inst Hlth Res, Old Rd Headington, Oxford, England.
Helmholtz Zentrum München,Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.
Esko, Tonu (författare)
Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.;Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA USA.
Mihailov, Evelin (författare)
University of Tartu,Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
Fred Hutchinson Cancer Research Center,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
Jackson, Rebecca D. (författare)
Ohio State University,Ohio State Univ, Dept Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
Stahl, Eli (författare)
Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
Mueller-Nurasyid, Martina (författare)
DZHK, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Dept Med 1, Univ Hosp Grosshadern, Munich, Germany.
Strauch, Konstantin (författare)
Helmholtz Zentrum München,Ludwig-Maximilian University of Munich,Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany.
Varga, Tibor V. (författare)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci, Ctr Diabet, Genet & Mol Epidemiol Unit, Malmo, Sweden.
Waldenberger, Melanie (författare)
Helmholtz Zentrum München,Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.
Zeng, Lingyao (författare)
German Centre for Cardiovascular Research,Technical University of Munich,Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.
Chowdhury, Rajiv (författare)
University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.
Salomaa, Veikko (författare)
Finnish National Institute for Health and Welfare,Natl Inst Hlth & Welf THL, Helsinki, Finland.
Ford, Ian (författare)
University of Glasgow,Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland.
Jukema, J. Wouter (författare)
Leiden University Medical Centre,Leiden Univ, Med Ctr, Leiden & Interuniv Cardiol Inst Netherlands, Dept Cardiol, Utrecht, Netherlands.
Amouyel, Philippe (författare)
University of Lille Nord de France,Univ Lille, INSERM, CHU Lille, Inst Pasteur Lille,RID AGE U1167, Lille, France.
Kontto, Jukka (författare)
Finnish National Institute for Health and Welfare
Nordestgaard, Borge G. (författare)
Copenhagen Univ Hosp & Med Sci, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
Ferrieres, Jean (författare)
Toulouse Univ, Sch Med, Toulouse, France.
Saleheen, Danish (författare)
Center for Non-Communicable Diseases,University of Pennsylvania,Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.;Ctr Noncommunicable Dis, Karachi, Pakistan.
Sattar, Naveed (författare)
University of Glasgow,Univ Glasgow, Glasgow Cardiovasc Res Ctr, British Heart Fdn, Glasgow, Lanark, Scotland.
Surendran, Praveen (författare)
Ludwig-Maximilian University of Munich,Ludwig Maximilians Univ Munchen, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany.
Wagner, Aline (författare)
University of Strasbourg,Univ Strasbourg, Dept Epidemiol & Publ Hlth, Strasbourg, France.
Young, Robin (författare)
University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.
Howson, Joanna M. M. (författare)
University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.
Butterworth, Adam S. (författare)
University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.;Univ Cambridge, Res Unit Donor Hlth & Genom, Natl Inst Hlth Res Blood & Transplant, Cambridge, England.
Danesh, John (författare)
University of Cambridge,Wellcome Trust Sanger Institute,Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.;Univ Cambridge, Res Unit Donor Hlth & Genom, Natl Inst Hlth Res Blood & Transplant, Cambridge, England.;Wellcome Trust Sanger Inst, Cambridge, England.
Ardissino, Diego (författare)
Parma University Hospital,Parma Univ Hosp, Parma, Italy.
Bottinger, Erwin P. (författare)
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
Erbel, Raimund (författare)
University Hospital Essen,Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
Franks, Paul W. (författare)
Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,Norrland University Hospital,Lund Univ, Dept Clin Sci, Ctr Diabet, Genet & Mol Epidemiol Unit, Malmo, Sweden.;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
Girelli, Domenico (författare)
University of Verona,Univ Verona, Sect Internal Med, Dept Med, Verona, Italy.
Academic Medical Center of University of Amsterdam (AMC),Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.
Kastrati, Adnan (författare)
Technical University of Munich,Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
Lieb, Wolfgang (författare)
University of Kiel,Christian Albrechts Univ Kiel, Inst Epidemiol & Biobank Popgen, Kiel, Germany.
Meitinger, Thomas (författare)
German Centre for Cardiovascular Research,Helmholtz Zentrum München,Technical University of Munich,DZHK, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Human Genet, Neuherberg, Germany.;Tech Univ Munich, Inst Human Genet, Munich, Germany.
Kraus, William E. (författare)
Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.;Duke Univ, Dept Med, Div Cardiol, Durham, NC USA.
Shah, Svati H. (författare)
Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.;Duke Univ, Dept Med, Div Cardiol, Durham, NC USA.
McPherson, Ruth (författare)
University of Ottawa,Univ Ottawa, Inst Heart, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.
Orho-Melander, Marju (författare)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmo, Malmo, Sweden.
Melander, Olle (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.
Metspalu, Andres (författare)
University of Tartu,Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Inst Mol & Cell Biol, Tartu, Estonia.
Palmer, Colin N. A. (författare)
University of Dundee,Univ Dundee, Hosp & Med Sch, Med Res Inst, Dundee, Scotland.
Peters, Annette (författare)
Helmholtz Zentrum München,German Centre for Cardiovascular Research,DZHK, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.
Rader, Daniel J. (författare)
University of Pennsylvania,Univ Penn, Dept Genet, Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA.
Reilly, Muredach P. (författare)
Columbia University,Columbia Univ, Dept Med, Div Cardiol, New York, NY USA.;Columbia Univ, Irving Inst Clin & Translat Res, New York, NY USA.
Loos, Ruth J. F. (författare)
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
Reiner, Alex P. (författare)
Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Roden, Dan M. (författare)
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.;Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.
Tardif, Jean-Claude (författare)
University Of Quebec In Montreal,Montreal Heart Institute,Univ Montreal, Fac Med, Dept Med, Montreal, PQ, Canada.;Montreal Heart Inst, Montreal, PQ, Canada.
Thompson, John R. (författare)
University of Leicester,Glenfield Hospital,Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.;Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
Wareham, Nicholas J. (författare)
Addenbrookes Hosp, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England.
Watkins, Hugh (författare)
University of Oxford,Wellcome Trust Centre for Human Genetics,Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
Willer, Cristen J. (författare)
University Of Quebec In Montreal,University of Michigan,Univ Montreal, Fac Med, Dept Med, Montreal, PQ, Canada.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
Samani, Nilesh J. (författare)
University of Leicester,Glenfield Hospital,Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England.
Schunkert, Heribert (författare)
Technical University of Munich,German Centre for Cardiovascular Research,Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK, Munich, Germany.
Deloukas, Panos (författare)
King Abdulaziz University,Queen Mary University,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence R, Jeddah, Saudi Arabia.
Kathiresan, Sekar (författare)
Broad Institute,Massachusetts General Hospital,Harvard Medical School,Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
Dube, Marie Pierre (författare)
University Of Quebec In Montreal,Montreal Heart Institute
Asselbergs, Folkert W (författare)
University Medical Center Utrecht,Interuniversity Cardiology Institute of the Netherlands,University College London
Merlini, Pier Angelica (författare)
Niguarda Hospital
Müller-Nurasyid, Martina (författare)
University Hospital Munich,German Centre for Cardiovascular Research,Helmholtz Zentrum München
van Iperen, Erik Pa (författare)
Academic Medical Center of University of Amsterdam (AMC)
Schadt, Eric (författare)
Icahn School of Medicine at Mount Sinai
Van Capelleveen, Julian C. (författare)
Academic Medical Center of University of Amsterdam (AMC)
Loos, Ruth J F (författare)
Icahn School of Medicine at Mount Sinai
Schick, Ursula M (författare)
Fred Hutchinson Cancer Research Center,Icahn School of Medicine at Mount Sinai
Escher, Stefan A (författare)
Lund University
Stahl, Eli A (författare)
Icahn School of Medicine at Mount Sinai
Johnson, Andrew D (författare)
National Heart Lung and Blood Institute
Doney, Alex S F (författare)
University of Dundee
Donnelly, Louise A (författare)
University of Dundee
Roden, Dan M (författare)
Vanderbilt University
Shah, Svati H (författare)
Duke University
Franzén, Oscar (författare)
Clinical Gene Networks AB,Icahn School of Medicine at Mount Sinai
van Zuydam, Natalie R. (författare)
University of Oxford
König, Inke R. (författare)
German Centre for Cardiovascular Research,University of Lübeck
Shaffer, Christian M. (författare)
Vanderbilt University
Hall, Alistair S (författare)
University of Leeds
Bottinger, Erwin P (författare)
Icahn School of Medicine at Mount Sinai
Björkegren, Johan L M (författare)
Karolinska Institutet,Clinical Gene Networks AB,Icahn School of Medicine at Mount Sinai,University of Tartu
Wareham, Nicholas J (författare)
Addenbrooke's Hospital
Reiner, Alex P (författare)
Fred Hutchinson Cancer Research Center,University of Washington
Denny, Josh C (författare)
Vanderbilt University
Reilly, Dermot F (författare)
Merck Sharp And Dohme Corp., US
Kraus, William E (författare)
Duke University
Esko, Tõnu (författare)
University of Tartu,Broad Institute,Harvard Medical School,Boston Children's Hospital
Robertson, Neil R (författare)
University of Oxford,Wellcome Trust Centre for Human Genetics
Masca, Nicholas G D (författare)
University of Leicester,Glenfield Hospital
Nelson, Christopher P (författare)
University of Leicester,Glenfield Hospital
Ferrières, Jean (författare)
University of Toulouse
Nordestgaard, Børge G (författare)
Copenhagen University Hospital
El Mokhtari, Nour Eddine (författare)
imland Klinik Rendsburg
Jöckel, Karl-Heinz (författare)
University Hospital Essen
Jansson, Jan-Hakan (författare)
Umea Univ, Res Unit Skelleftea, Dept Publ Hlth & Clin Med, Umea, Sweden.
BACKGROUND Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011. Suggestive association signals were replicated in an additional 30,533 cases and 42,530 control subjects. To evaluate pleiotropy, we tested CAD loci for association with cardiovascular risk factors (lipid traits, blood pressure phenotypes, body mass index, diabetes, and smoking behavior), as well as with other diseases/traits through interrogation of currently available genome-wide association study catalogs. RESULTS We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP). Risk allele frequencies ranged from 0.15 to 0.86, and odds ratio per copy of the risk allele ranged from 1.04 to 1.09. Of 62 new and known CAD loci, 24 (38.7%) showed statistical association with a traditional cardiovascular risk factor, with some showing multiple associations, and 29 (47%) showed associations at p < 1 x 10(-4) with a range of other diseases/traits. CONCLUSIONS We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk. (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)