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Sökning: onr:"swepub:oai:DiVA.org:umu-134616" > Histological improv...

Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis a cohort study

Danielsson Borssén, Åsa, 1977- (författare)
Umeå universitet, Medicin
Palmqvist, Richard, (författare)
Umeå universitet, Patologi
Kechagias, Stergios, (författare)
Department of Gastroenterology and Hepatology, Department of Medical and Health Sciences, Linköping University
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Marschall, Hanns-Ulrich, (författare)
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
Bergquist, Annika, (författare)
Department of Medicine, Section of Hepatology and Gastroenterology, Karolinska Institutet
Rorsman, Fredrik, (författare)
Department of Medical Sciences, Section of Gastroenterology and Hepatology, Uppsala University
Weiland, Ola, (författare)
Division of Infectious Diseases, Department of Medicine, Karolinska Institutet
Verbaan, Hans, (författare)
Gastroenterology Division, Department of Clinical Sciences, Lund University
Nyhlin, Nils, (författare)
Department of Medicine, Section of Hepatology and Gastroenterology, Örebro University Hospital and Faculty of Medicine and Health, Örebro University
Nilsson, Emma, (författare)
Gastroenterology Division, Department of Clinical Sciences, Lund University
Werner, Mårten, (författare)
Umeå universitet, Medicin
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2017
Engelska.
Ingår i: Medicine (Baltimore, Md.). - 0025-7974 .- 1536-5964. ; 96:34
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p><strong>Objectives </strong>Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that if left untreated may lead to the development of cirrhosis. Previous studies on AIH patients have suggested that fibrosis and even cirrhosis can be reversed by medical treatment. The aim of this study was to evaluate the efficacy of medical treatment for protection of developing fibrosis and cirrhosis.</p><p><strong>Methods</strong> Two hundred fifty-eight liver biopsies from 101 patients (72 women, 29 men) were analysed by a single pathologist and classified accordingly to the Ishak grading (inflammation) and staging (fibrosis) system. Liver histology was stratified according to the temporal changes of fibrosis stage (increased, decreased or stable), and groups were compared.</p><p><strong>Results</strong> Complete or partial response to medical treatment was 94.9%. Reduction of fibrosis stage from the first to the last biopsy was seen in 63 patients (62.4%). We found an association between a reduction in fibrosis stage and continuous glucocorticoid medication, as well as lowered scores of inflammation at last biopsy. Twenty-one patients had cirrhosis (Ishak stage 6) at least in one of the previous biopsies, but only five patients at the last biopsy.</p><p><strong>Conclusions</strong> Histological improvement is common in AIH patients that respond to medical treatment, and a reduction or stabilization of fibrosis stage occurs in about 2/3 of such patients.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

autoimmune hepatitis
autoimmune liver disease
cirrhosis
fibrosis
inflammation

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