SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-146234"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-146234" > A Large-Scale Multi...

Abstract Ämnesord
Stäng  
  • Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined similar to 18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 x 10(-8)) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 x 10(-8)). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling MSRA, EBF2).

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

blood pressure
GWAS
GxE interactions
lifestyle
multi-ancestry
smoking

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...
Sung, Yun J.
Winkler, Thomas ...
de las Fuentes, ...
Bentley, Amy R.
Brown, Michael R ...
Kraja, Aldi T.
visa fler...
Schwander, Karen
Ntalla, Ioanna
Guo, Xiuqing
Franceschini, No ...
Lu, Yingchang
Cheng, Ching-Yu
Sim, Xueling
Vojinovic, Dina
Marten, Jonathan
Musani, Solomon ...
Li, Changwei
Feitosa, Mary F.
Kilpelainen, Tuo ...
Richard, Melissa ...
Noordam, Raymond
Aslibekyan, Stel ...
Aschard, Hugues
Bartz, Traci M.
Dorajoo, Rajkuma ...
Liu, Yongmei
Manning, Alisa K ...
Rankinen, Tuomo
Smith, Albert Ve ...
Tajuddin, Salman ...
Tayo, Bamidele O ...
Warren, Helen R.
Zhao, Wei
Zhou, Yanhua
Matoba, Nana
Sofer, Tamar
Alver, Maris
Amini, Marzyeh
Boissel, Mathild ...
Chai, Jin Fang
Chen, Xu
Divers, Jasmin
Gandin, Ilaria
Gao, Chuan
Giulianini, Fran ...
Goel, Anuj
Harris, Sarah E.
Hartwig, Fernand ...
Horimoto, Andrea ...
Hsu, Fang-Chi
Jackson, Anne U.
Kahonen, Mika
Kasturiratne, An ...
Kuhnel, Brigitte
Leander, Karin
Lee, Wen-Jane
Lin, Keng-Hung
Luan, Jian' an
McKenzie, Colin ...
Meian, He
Nelson, Christop ...
Rauramaa, Rainer
Schupf, Nicole
Scott, Robert A.
Sheu, Wayne H. H ...
Stancakova, Alen ...
Takeuchi, Fumihi ...
van der Most, Pe ...
Varga, Tibor V.
Wang, Heming
Wang, Yajuan
Ware, Erin B.
Weiss, Stefan
Wen, Wanqing
Yanek, Lisa R.
Zhang, Weihua
Zhao, Jing Hua
Afaq, Saima
Alfred, Tamuno
Amin, Najaf
Arking, Dan
Aung, Tin
Barr, R. Graham
Bielak, Lawrence ...
Boerwinkle, Eric
Bottinger, Erwin ...
Braund, Peter S.
Brody, Jennifer ...
Broeckel, Ulrich
Cabrera, Claudia ...
Cade, Brian
Caizheng, Yu
Campbell, Archie
Canouil, Mickael
Chakravarti, Ara ...
Chauhan, Ganesh
Christensen, Kaa ...
Cocca, Massimili ...
Collins, Francis ...
Connell, John M.
de Mutsert, Rene ...
de Silva, H. Jan ...
Debette, Stephan ...
Dorr, Marcus
Duan, Qing
Eaton, Charles B ...
Ehret, Georg
Evangelou, Evang ...
Faul, Jessica D.
Fisher, Virginia ...
Forouhi, Nita G.
Franco, Oscar H.
Friedlander, Yec ...
Gao, He
Gigante, Bruna
Graff, Misa
Gu, C. Charles
Gu, Dongfeng
Gupta, Preeti
Hagenaars, Saski ...
Harris, Tamara B ...
He, Jiang
Heikkinen, Sami
Heng, Chew-Kiat
Hirata, Makoto
Hofman, Albert
Howard, Barbara ...
Hunt, Steven
Irvin, Marguerit ...
Jia, Yucheng
Joehanes, Roby
Justice, Anne E.
Katsuya, Tomohir ...
Kaufman, Joel
Kerrison, Nicola ...
Khor, Chiea Chue ...
Koh, Woon-Puay
Koistinen, Heikk ...
Komulainen, Pirj ...
Kooperberg, Char ...
Krieger, Jose E.
Kubo, Michiaki
Kuusisto, Johann ...
Langefeld, Carl ...
Langenberg, Clau ...
Launer, Lenore J ...
Lehne, Benjamin
Lewis, Cora E.
Li, Yize
Lim, Sing Hui
Lin, Shiow
Liu, Ching-Ti
Liu, Jianjun
Liu, Jingmin
Liu, Kiang
Liu, Yeheng
Loh, Marie
Lohman, Kurt K.
Long, Jirong
Louie, Tin
Magi, Reedik
Mahajan, Anubha
Meitinger, Thoma ...
Metspalu, Andres
Milani, Lili
Momozawa, Yukihi ...
Morris, Andrew P ...
Mosley, Thomas H ...
Munson, Peter
Murray, Alison D ...
Nalls, Mike A.
Nasri, Ubaydah
Norris, Jill M.
North, Kari
Ogunniyi, Adesol ...
Padmanabhan, San ...
Palmas, Walter R ...
Palmer, Nicholet ...
Pankow, James S.
Pedersen, Nancy ...
Peters, Annette
Peyser, Patricia ...
Polasek, Ozren
Raitakari, Olli ...
Renström, Frida
Rice, Treva K.
Ridker, Paul M.
Robino, Antoniet ...
Robinson, Jennif ...
Rose, Lynda M.
Rudan, Igor
Sabanayagam, Cha ...
Salako, Babatund ...
Sandow, Kevin
Schmidt, Carsten ...
Schreiner, Pamel ...
Scott, William R ...
Seshadri, Sudha
Sever, Peter
Sitlani, Colleen ...
Smith, Jennifer ...
Snieder, Harold
Starr, John M.
Strauch, Konstan ...
Tang, Hua
Taylor, Kent D.
Teo, Yik Ying
Tham, Yih Chung
Ultterlinden, An ...
Waldenberger, Me ...
Wang, Lihua
Wang, Ya X.
Bin Wei, Wen
Williams, Christ ...
Wilson, Gregory
Wojczynski, Mary ...
Yao, Jie
Yuan, Jian-Min
Zonderman, Alan ...
Becker, Diane M.
Boehnke, Michael
Bowden, Donald W ...
Chambers, John C ...
Chen, Yii-Der Id ...
de Faire, Ulf
Deary, Ian J.
Esko, Tonu
Farrall, Martin
Forrester, Terre ...
Franks, Paul W.
Freedman, Barry ...
Froguel, Philipp ...
Gasparini, Paolo
Gieger, Christia ...
Horta, Bernardo ...
Hung, Yi-Jen
Jonas, Jost B.
Kato, Norihiro
Kooner, Jaspal S ...
Laakso, Markku
Lehtimaki, Terho
Liang, Kae-Woei
Magnusson, Patri ...
Newman, Anne B.
Oldehinkel, Albe ...
Pereira, Alexand ...
Redline, Susan
Rettig, Rainer
Samani, Nilesh J ...
Scott, James
Shu, Xiao-Ou
van der Harst, P ...
Wagenknecht, Lyn ...
Wareham, Nichola ...
Watkins, Hugh
Weir, David R.
Wickremasinghe, ...
Wu, Tangchun
Zheng, Wei
Kamatani, Yoichi ...
Laurie, Cathy C.
Bouchard, Claude
Cooper, Richard ...
Evans, Michele K ...
Gudnason, Vilmun ...
Kardia, Sharon L ...
Kritchevsky, Ste ...
Levy, Daniel
O'Connell, Jeff ...
Psaty, Bruce M.
van Dam, Rob M.
Sims, Mario
Arnett, Donna K.
Mook-Kanamori, D ...
Kelly, Tanika N.
Fox, Ervin R.
Hayward, Carolin ...
Fornage, Myriam
Rotimi, Charles ...
Province, Michae ...
van Duijn, Corne ...
Tai, E. Shyong
Wong, Tien Yin
Loos, Ruth J. F.
Reiner, Alex P.
Rotter, Jerome I ...
Zhu, Xiaofeng
Bierut, Laura J.
Gauderman, W. Ja ...
Caulfield, Mark ...
Elliott, Paul
Rice, Kenneth
Munroe, Patricia ...
Morrison, Alanna ...
Cupples, L. Adri ...
Rao, Dabeeru C.
Chasman, Daniel ...
Kilpeläinen, Tuo ...
Samani, NJ
Aschard, H
Zheng, W
Giulianini, F
de Faire, U
Bin Wei, W
Hayward, C
Hartwig, FP
Goel, A
Kuhnel, B
Padmanabhan, S
Taylor, KD
Rice, K
Bottinger, EP
Zhao, W
Brown, MR
Zhu, XF
Horta, BL
Jackson, AU
Cocca, M
Lohman, KK
Smith, AV
Sitlani, CM
Liu, JM
Kuusisto, J
Louie, T
Ntalla, I
Wang, YX
Koh, WP
Liu, YH
Polasek, O
Gasparini, P
Collins, FS
Tajuddin, SM
Heikkinen, S
Ridker, PM
Franceschini, N
Musani, SK
Hagenaars, SP
Barr, RG
Lewis, CE
Esko, T
Matoba, N
Horimoto, ARVR
Watkins, H
Forrester, T
Alfred, T
Arking, D
Chai, JF
Robinson, JG
Li, YZ
Hsu, FC
Ehret, G
Langenberg, C
Mahajan, A
Guo, XQ
Rao, DC
Becker, DM
Feitosa, MF
Lin, S
Chen, YDI
Boerwinkle, E
Irvin, MR
Kasturiratne, A
Magnusson, PKE
Hofman, A
Farrall, M
Lehtimaki, T
Peters, A
Varga, TV
Tayo, BO
He, MA
Friedlander, Y
Teo, YY
Kamatani, Y
Rettig, R
Smith, JA
Wang, LH
Sandow, K
Langefeld, CD
Wickremasinghe, ...
Ware, EB
Brody, JA
Alver, M
Chakravarti, A
Lehne, B
Nalls, MA
Franks, PW
Kahonen, M
Faul, JD
Hunt, S
Kardia, SLR
Liu, JJ
Laakso, M
Justice, AE
Rotimi, CN
Cabrera, CP
Raitakari, OT
Kubo, M
van der Most, PJ
Liu, K
Pankow, JS
Gu, CC
Oldehinkel, AJ
Aslibekyan, S
Chen, X
Chasman, DI
Scott, RA
Chauhan, G
Pereira, AC
Wong, TY
Rose, LM
Williams, C
Bouchard, C
Franco, OH
Robino, A
Wu, TC
Weiss, S
Kooner, JS
Pedersen, NL
Zhou, YH
Newman, AB
Braund, PS
Zonderman, AB
Jonas, JB
Lee, WJ
Wojczynski, MK
Forouhi, NG
Metspalu, A
Kelly, TN
McKenzie, CA
Liu, CT
van Duijn, CM
Liu, YM
Vojinovic, D
Noordam, R
Mosley, TH
Rankinen, T
Laurie, CC
Sabanayagam, C
Boehnke, M
Renstrom, F
Stancakova, A
Chambers, JC
Wang, YJ
Amini, M
Bowden, DW
Loos, RJF
Komulainen, P
Sofer, T
Elliott, P
van der Harst, P
Palmas, WR
Sever, P
Yanek, LR
Joehanes, R
Yu, CZ
Katsuya, T
Long, JR
Cooper, RS
Schreiner, PJ
Strauch, K
Shu, XO
Morrison, AC
Nasri, U
Tham, YC
Amin, N
Evangelou, E
Ogunniyi, A
Hung, YJ
Wilson, G
Sung, YJ
Liang, KW
Cade, B
Wagenknecht, LE
Meitinger, T
Arnett, DK
Campbell, A
Province, MA
Debette, S
Caulfield, MJ
Lim, SH
Tai, ES
Marten, J
Milani, L
Bielak, LF
Munroe, PB
Warren, HR
Munson, P
Connell, JM
Dorr, M
Boissel, M
Afaq, S
Levy, D
Palmer, ND
Broeckel, U
Kilpelainen, TO
Bartz, TM
Gu, DF
Scott, WR
Winkler, TW
Li, CW
Zhao, JH
Snieder, H
Christensen, K
Gao, H
Kerrison, ND
Canouil, M
Schupf, N
Takeuchi, F
Gupta, P
He, J
North, K
Leander, K
Fisher, VA
Schmidt, CO
Ultterlinden, AG
Gudnason, V
Gigante, B
Tang, H
Waldenberger, M
Yuan, JM
Howard, BV
Reiner, AP
Koistinen, HA
Graff, M
Froguel, P
Sheu, WHH
Luan, JA
Murray, AD
Harris, TB
Redline, S
Deary, IJ
de Silva, HJ
Rauramaa, R
Norris, JM
van Dam, RM
Mook-Kanamori, D ...
Momozawa, Y
Peyser, PA
Wen, WQ
Gandin, I
Harris, SE
Kooperberg, C
Cheng, CY
Gieger, C
Magi, R
Kraja, AT
Kato, N
Lu, YC
Freedman, BI
Rice, TK
Aung, T
Lin, KH
Zhang, WH
de Mutsert, R
Cupples, LA
Duan, Q
Schwander, K
Yao, J
Scott, J
Weir, DR
Sim, XL
Fornage, M
Heng, CK
Divers, J
Kritchevsky, SB
Fox, ER
Rotter, JI
Dorajoo, R
Gauderman, WJ
Wareham, NJ
Krieger, JE
Hirata, M
de Las Fuentes, ...
Eaton, CB
Gao, C
Salako, BL
Bentley, AR
Nelson, CP
Evans, MK
Psaty, BM
Wang, HM
Khor, CC
O'Connell, JR
Richard, MA
Manning, AK
Morris, AP
Rudan, I
Starr, JM
Sims, M
Jia, YC
Seshadri, S
Loh, M
Launer, LJ
Kaufman, J
Bierut, LJ
visa färre...
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
och Medicinsk geneti ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Endokrinologi oc ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
och Cell och molekyl ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
Artiklar i publikationen
American Journal ...
Av lärosätet
Umeå universitet
Lunds universitet

Sök utanför SwePub

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy