National University of Singapore, Singapore Eye Research Institute, Duke–NUS Medical School
Sim, Xueling, (författare)
National University Health System
Vojinovic, Dina, (författare)
Erasmus University Medical Center
Marten, Jonathan, (författare)
University of Edinburgh
Musani, Solomon K., (författare)
University of Mississippi Medical Center
Li, Changwei, (författare)
University of Georgia
Bentley, Amy R., (författare)
National Human Genome Research Institute
Brown, Michael R., (författare)
University of Texas
Schwander, Karen, (författare)
Washington University in St. Louis
Richard, Melissa A., (författare)
University of Texas
Noordam, Raymond, (författare)
Leiden University Medical Centre
Aschard, Hugues, (författare)
Harvard University, Pasteur Institute
Bartz, Traci M., (författare)
University of Washington
Bielak, Lawrence F., (författare)
University of Michigan
Dorajoo, Rajkumar, (författare)
A*Star, Genome Institute of Singapore (GIS)
Fisher, Virginia, (författare)
Boston University
Hartwig, Fernando P., (författare)
Federal University of Pelotas, University of Bristol
Horimoto, Andrea R.V.R., (författare)
University of São Paulo
Lohman, Kurt K., (författare)
Wake Forest University
Manning, Alisa K., (författare)
Harvard Medical School, Massachusetts General Hospital
Rankinen, Tuomo, (författare)
Pennington Biomedical Research Center
Smith, Albert V., (författare)
University of Iceland, Icelandic Heart Association
Tajuddin, Salman M., (författare)
National Institute on Aging, United States
Wojczynski, Mary K., (författare)
Washington University in St. Louis
Alver, Maris, (författare)
University of Tartu
Boissel, Mathilde, (författare)
University of Lille Nord de France
Cai, Qiuyin, (författare)
Vanderbilt University School of Medicine
Campbell, Archie, (författare)
University of Edinburgh
Chai, Jin Fang, (författare)
National University Health System
Chen, Xu, (författare)
Karolinska Institutet
Divers, Jasmin, (författare)
Wake Forest University
Gao, Chuan, (författare)
Wake Forest University
Goel, Anuj, (författare)
University of Oxford
Hagemeijer, Yanick, (författare)
University Medical Center Groningen
Harris, Sarah E., (författare)
University of Edinburgh
He, Meian, (författare)
Huazhong University of Science and Technology
Hsu, Fang Chi, (författare)
Wake Forest University
Jackson, Anne U., (författare)
University of Michigan
Kähönen, Mika, (författare)
University of Tampere, Tampere University Hospital
Kasturiratne, Anuradhani, (författare)
University of Kelaniya
Varga, Tibor V., (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, -lup-obsolete, LUDC (Lund University Diabetes Centre)-lup-obsolete, Lunds universitet, Lund University, Genetisk och molekylär epidemiologi, Genetic and Molecular Epidemiology, Skåne University Hospital
Franks, Paul W., (författare)
Forskargrupper vid Lunds universitet, Lund University Research Groups, -lup-obsolete, LUDC (Lund University Diabetes Centre)-lup-obsolete, Lunds universitet, Lund University, Genetisk och molekylär epidemiologi, Genetic and Molecular Epidemiology, Strategiska forskningsområden, Strategic Research Areas, EpiHealth: Epidemiology for Health, EpiHealth: Epidemiology for Health, Harvard University
Rice, Kenneth, (författare)
University of Washington
Morrison, Alanna C, (författare)
University of Texas
Elliott, Paul, (författare)
Imperial College London
Caulfield, Mark J., (författare)
Queen Mary University
Munroe, Patricia B., (författare)
Queen Mary University
Rao, Dabeeru C., (författare)
Washington University in St. Louis
Province, Michael A, (författare)
Washington University in St. Louis
Levy, Daniel, (författare)
National Heart Lung and Blood Institute, Framingham Heart Study
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
Ämnesord
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskaper -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)