The incidence of Cushing's disease : a nationwide Swedish study
Ragnarsson, Oskar (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Höybye, Charlotte (författare)
Karolinska Univ Hosp, Patient Area Endocrinol & Nephrol, Inflammat & Infect Theme, S-17176 Solna, Sweden;Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden
Engström, Britt E (författare)
Uppsala universitet,Endokrinologi och mineralmetabolism
Segerstedt, E(författare)
Akerman, AK (författare)
Karolinska Institutet
Burman, P(författare)
Bryngelsson, IL(författare)
Ekman, B(författare)
Dahlqvist, P(författare)
Petranek, D(författare)
Bensing, S (författare)
Karolinska Institutet
Hoybye, C (författare)
Karolinska Institutet
Johannsson, G(författare)
Follin, C(författare)
Olsson, DS(författare)
Erfurth, EM(författare)
Chantzichristos, D(författare)
Engstrom, BE(författare)
Ragnarsson, O(författare)
Schwarcz, E(författare)
Olsson, T(författare)
Papakokkinou, E(författare)
Petersson, M (författare)
Karolinska Institutet
Bonelli, L(författare)
Wahlberg, J(författare)
Berinder, K (författare)
Karolinska Institutet
Olsson, Daniel S, 1983 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Background: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden.Methods: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data.Results: Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4–1.8) cases per million. 1987–1995, 1996–2004, and 2005–2013, the mean annual incidence was 1.5 (1.1–1.8), 1.4 (1.0–1.7) and 2.0 (1.7–2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05).Conclusion: The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987–2004 was noticed. Whether this reflects a truly increased incidence of the disease, or simply an increased awareness, earlier recognition, and earlier diagnosis can, however, not be answered. This study also illustrates the importance of validation of the diagnosis of CD in epidemiological research.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)