SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-167291"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-167291" > Metabolic response ...

  • Björkblom, Benny,Umeå universitet, Kemiska institutionen (författare)

Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma

  • Artikel/kapitelEngelska2020

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-167291
  • 10.1038/s41416-019-0652-xdoi
  • 31819184pmid
  • urn:nbn:se:umu:diva-167291urn

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Published
  • 8
  • <p>BACKGROUND: High-grade gliomas are associated with poor prognosis. Tumour heterogeneity and invasiveness create challenges for effective treatment and use of systemically administrated drugs. Furthermore, lack of functional predictive response-assays based on drug efficacy complicates evaluation of early treatment responses.</p><p>METHODS: We used microdialysis to deliver cisplatin into the tumour and to monitor levels of metabolic compounds present in the tumour and non-malignant brain tissue adjacent to tumour, before and during treatment. In parallel, we collected serum samples and used multivariate statistics to analyse the metabolic effects.</p><p>RESULTS: We found distinct metabolic patterns in the extracellular fluids from tumour compared to non-malignant brain tissue, including high concentrations of a wide range of amino acids, amino acid derivatives and reduced levels of monosaccharides and purine nucleosides. We found that locoregional cisplatin delivery had a strong metabolic effect at the tumour site, resulting in substantial release of glutamic acid, phosphate, and spermidine and a reduction of cysteine levels. In addition, patients with long-time survival displayed different treatment response patterns in both tumour and serum. Longer survival was associated with low tumour levels of lactic acid, glyceric acid, ketoses, creatinine and cysteine. Patients with longer survival displayed lower serum levels of ketohexoses, fatty acid methyl esters, glycerol-3-phosphate and alpha-tocopherol, while elevated phosphate levels were seen in both tumour and serum during treatment.</p><p>CONCLUSION: We highlight distinct metabolic patterns associated with high-grade tumour metabolism, and responses to cytotoxic cisplatin treatment.</p>

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jonsson, Pär,Umeå universitet, Kemiska institutionen(SwePub:umu) (författare)
  • Tabatabaei, Pedram,Umeå universitet, Neurokirurgi(SwePub:umu) (författare)
  • Bergström, Per,Umeå universitet, Onkologi(SwePub:umu) (författare)
  • Johansson, Mikael,Umeå universitet, Onkologi(SwePub:umu) (författare)
  • Asklund, Thomas,Umeå universitet, Onkologi(SwePub:umu) (författare)
  • Bergenheim, A. Tommy,Umeå universitet, Neurokirurgi(SwePub:umu) (författare)
  • Antti, Henrik,1970-,Umeå universitet, Kemiska institutionen(SwePub:umu) (författare)

Sammanhörande titlar

  • Ingår i:British Journal of CancerNature Publishing Group0007-09201532-1827122:2, s. 221-232

Internetlänk

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy