SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-185754"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-185754" > Mixtures of persist...

  • Björvang, Richelle D.Karolinska Institutet,Karolinska University Hospital (författare)

Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-185754
  • urn:nbn:se:umu:diva-185754urn
  • https://doi.org/10.1016/j.chemosphere.2021.131125DOI
  • https://lup.lub.lu.se/record/cc389eb8-7107-441c-a6e3-31dd9efaf54eURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:234467953URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147562105URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • gratis
  • gratis
  • Persistent organic pollutants (POPs) are industrial chemicals with long half-lives. Early life exposure to POPs has been associated with adverse effects. Fetal exposure is typically estimated based on concentrations in maternal serum or placenta and little is known on the actual fetal exposure. We measured the concentrations of nine organochlorine pesticides (OCPs), ten polychlorinated biphenyl (PCB) congeners, and polybrominated diphenyl ether (PBDE) congeners by gas chromatography – tandem mass spectrometry in maternal serum, placenta, and fetal tissues (adipose tissue, liver, heart, lung and brain) in 20 pregnancies that ended in stillbirth (gestational weeks 36–41). The data were combined with our earlier data on perfluoroalkyl substances (PFASs) in the same cohort (Mamsen et al. 2019). HCB, p,p’-DDE, PCB 138 and PCB 153 were quantified in all samples of maternal serum, placenta and fetal tissues. All 22 POPs were detected in all fetal adipose tissue samples, even in cases where they could not be detected in maternal serum or placenta. Tissue:serum ratios were significantly higher in later gestations, male fetuses, and pregnancies with normal placental function. OCPs showed the highest tissue:serum ratios and PFAS the lowest. The highest chemical burden was found in adipose tissue and lowest in the brain. Overall, all studied human fetuses were intrinsically exposed to mixtures of POPs. Tissue:serum ratios were significantly modified by gestational age, fetal sex and placental function. Importantly, more chemicals were detected in fetal tissues compared to maternal serum and placenta, implying that these proxy samples may provide a misleading picture of actual fetal exposures.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vinnars, Marie-ThereseUmeå universitet,Institutionen för klinisk vetenskap,Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Obstetrics and Gynecology Ornsköldsviks Hospital, Sweden(Swepub:umu)mavi0140 (författare)
  • Papadogiannakis, NikosKarolinska Institutet,Karolinska University Hospital (författare)
  • Gidlöf, SebastianKarolinska Institutet,Karolinska University Hospital (författare)
  • Mamsen, Linn SaltoLaboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark,University of Copenhagen,Copenhagen University Hospital (författare)
  • Mucs, DanielKarolinska Institutet (författare)
  • Kiviranta, HannuDepartment of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare (författare)
  • Rantakokko, PanuDepartment of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare (författare)
  • Ruokojärvi, PäiviDepartment of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland,Finnish National Institute for Health and Welfare (författare)
  • Lindh, Christian H.Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine (författare)
  • Andersen, Claus YdingLaboratory of Reproductive Biology, Section 5712, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen and University of Copenhagen, Rigshospitalet, Copenhagen, Denmark,University of Copenhagen,Copenhagen University Hospital (författare)
  • Damdimopoulou, PauliinaKarolinska Institutet,Karolinska University Hospital (författare)
  • Vinnars, Marie ThereseUmeå University,Karolinska Institutet,Karolinska University Hospital (författare)
  • Kiviranta, H (författare)
  • Mucs, D (författare)
  • Andersen, CY (författare)
  • Papadogiannakis, N (författare)
  • Rantakokko, P (författare)
  • Vinnars, MT (författare)
  • Lindh, CH (författare)
  • Mamsen, LS (författare)
  • Damdimopoulou, P (författare)
  • Björvang, RD (författare)
  • Gidlöf, SKarolinska Institutet (författare)
  • Ruokojärvi, P (författare)
  • Bjorvang, RD (författare)
  • Ruokojarvi, P (författare)
  • Gidlof, SKarolinska Institutet (författare)
  • Karolinska InstitutetKarolinska University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Chemosphere: Elsevier2830045-65351879-1298

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy