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Sökning: onr:"swepub:oai:DiVA.org:umu-185763" > The genetic organiz...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008590naa a2200733 4500
001oai:DiVA.org:umu-185763
003SwePub
008210705s2021 | |||||||||||000 ||eng|
024a urn:nbn:se:umu:diva-1857632 urn
024a https://doi.org/10.7554/eLife.664662 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Fjell, Anders M.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway4 aut
2451 0a The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change
264 1b eLife Sciences Publications,c 2021
338 a electronic2 rdacarrier
506 a gratis
506 a gratis
520 a Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single nucleotide polymorphisms-based analyses of 38127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
653 a Aging
653 a Brain
653 a Development
653 a Genetics
653 a Hippocampus
653 a lifespan
653 a Subcortex
700a Grydeland, Håkonu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Wang, Yunpengu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Amlien, Ingeu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Bartrés-Faz, Davidu Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain4 aut
700a Brandmaier, Andreas M.u Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom4 aut
700a Düzel, Sandrau Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany4 aut
700a Elman, Jeremyu Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
700a Franz, Carolu Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
700a Håberg, Asta K.u Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway4 aut
700a Kietzmann, Tim C.u MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands4 aut
700a Kievit, Rogier A.u MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom4 aut
700a Kremen, William S.u Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States; Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
700a Krogsrud, Stine K.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Kühn, Simoneu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany4 aut
700a Lindenberger, Ulmanu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom4 aut
700a Macià, Didacu Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain4 aut
700a Mowinckel, Athanasia M.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Nyberg, Lars,d 1966-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001
700a Panizzon, Matthew S.u Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States4 aut
700a Solé-Padullés, Cristinau Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain4 aut
700a Sørensen, Øysteinu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Westerhausen, Renéu Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 aut
700a Walhovd, Kristine B.u Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway4 aut
710a Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norwayb Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway4 org
773t eLIFEd : eLife Sciences Publicationsg 10q 10x 2050-084X
856u https://doi.org/10.7554/eLife.66466
856u http://umu.diva-portal.org/smash/get/diva2:1577904/FULLTEXT01.pdf
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185763x lärosäteslänky Till lärosätets (umu) databas
8564 8u https://doi.org/10.7554/eLife.66466

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