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Sökning: onr:"swepub:oai:DiVA.org:umu-189575" > A common polymorphi...

A common polymorphism in the dopamine transporter gene predicts working memory performance and in vivo dopamine integrity in aging

Karalija, Nina, 1984- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Köhncke, Ylva (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Düzel, Sandra (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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Bertram, Lars (författare)
Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Papenberg, Goran (författare)
Aging Research Center, Karolinska Institutet & Stockholm University, Solna, Sweden
Demuth, Ilja (författare)
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany; Charité – Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
Lill, Christina M. (författare)
Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, UK, London, United Kingdom
Johansson, Jarkko (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
Riklund, Katrine, MD, PhD, Professor, 1963- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
Lövdén, Martin (författare)
Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
Bäckman, Lars (författare)
Aging Research Center, Karolinska Institutet & Stockholm University, Solna, Sweden
Nyberg, Lars, 1966- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Diagnostisk radiologi
Lindenberger, Ulman (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and, UK, London, United Kingdom
Brandmaier, Andreas M. (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and, UK, London, United Kingdom
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Academic Press, 2021
2021
Engelska.
Ingår i: NeuroImage. - : Academic Press. - 1053-8119 .- 1095-9572. ; 245
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Dopamine (DA) integrity is suggested as a potential cause of individual differences in working memory (WM) performance among older adults. Still, the principal dopaminergic mechanisms giving rise to WM differences remain unspecified. Here, 61 single-nucleotide polymorphisms, located in or adjacent to various dopamine-related genes, were assessed for their links to WM performance in a sample of 1313 adults aged 61–80 years from the Berlin Aging Study II. Least Absolute Shrinkage and Selection Operator (LASSO) regression was conducted to estimate associations between polymorphisms and WM. Rs40184 in the DA transporter gene, SLC6A3, showed allelic group differences in WM, with T-carriers performing better than C homozygotes (p<0.01). This finding was replicated in an independent sample from the Cognition, Brain, and Aging study (COBRA; baseline: n = 181, ages: 64–68 years; 5-year follow up: n = 129). In COBRA, in vivo DA integrity was measured with 11C-raclopride and positron emission tomography. Notably, WM as well as in vivo DA integrity was higher for rs40184 T-carriers at baseline (p<0.05 for WM and caudate and hippocampal D2-receptor availability) and at the 5-year follow-up (p<0.05 for WM and hippocampal D2 availability). Our findings indicate that individual differences in DA transporter function contribute to differences in WM performance in old age, presumably by regulating DA availability.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

11C-raclopride
Dopamine D2 receptor
Dopamine transporter
Single-nucleotide polymorphisms
Working memory
11 C-raclopride

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