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Sökning: onr:"swepub:oai:DiVA.org:umu-190112" > Individual variatio...

Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change

Vidal-Pineiro, Didac (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Wang, Yunpeng (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Krogsrud, Stine K. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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Amlien, Inge K. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Baaré, William FC (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark
Bartres-Faz, David (författare)
Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Bertram, Lars (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lubeck, Germany
Brandmaier, Andreas M. (författare)
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Drevon, Christian A. (författare)
Department of Nutrition, Inst Basic Med Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Oslo, Norway
Düzel, Sandra (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Ebmeier, Klaus (författare)
Department of Psychiatry, University of Oxford, Oxford, United Kingdom
Henson, Richard N. (författare)
MRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Junqué, Carme (författare)
Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
Kievit, Rogier Andrew (författare)
MRC Cognition and Brain Sciences Unit and Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands
Kühn, Simone (författare)
Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Leonardsen, Esten (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Lindenberger, Ulman (författare)
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Madsen, Kathrine S. (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
Magnussen, Fredrik (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Mowinckel, Athanasia Monika (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Nyberg, Lars, 1966- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi,Diagnostisk radiologi
Roe, James M. (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Segura, Barbara (författare)
Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
Smith, Stephen M. (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Sørensen, Øystein (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Suri, Sana (författare)
Wellcome Centre for Integrative Neuroimaging (WIN FMRIB), University of Oxford, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom
Westerhausen, Rene (författare)
Section for Cognitive Neuroscience and Neuropsychology, Department of Psychology, University of Oslo, Oslo, Norway
Zalesky, Andrew (författare)
Department of Biomedical Engineering, Faculty of Engineering and IT, The University of Melbourne, Melbourne, Australia
Zsoldos, Enikő (författare)
Wellcome Centre for Integrative Neuroimaging, Departments of Psychiatry and Clinical Neuroscience, University of Oxford, Oxford, United Kingdom
Walhovd, Kristine Beate (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway
Fjell, Anders (författare)
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of radiology and nuclear medicine, Oslo University Hospital, Oslo, Norway
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 (creator_code:org_t)
eLife Sciences Publications, 2021
2021
Engelska.
Ingår i: eLIFE. - : eLife Sciences Publications. - 2050-084X. ; 10
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Brain age is a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher-than-expected brain age is thought partially to reflect above-average rate of brain aging. Here, we explicitly tested this assumption in two indepen-dent large test datasets (UK Biobank [main] and Lifebrain [replication]; longitudinal observations ≈ 2750 and 4200) by assessing the relationship between cross-sectional and longitudinal estimates of brain age. Brain age models were estimated in two different training datasets (n ≈ 38,000 [main] and 1800 individuals [replication]) based on brain structural features. The results showed no association between cross-sectional brain age and the rate of brain change measured longitudinally. Rather, brain age in adulthood was associated with the congenital factors of birth weight and polygenic scores of brain age, assumed to reflect a constant, lifelong influence on brain structure from early life. The results call for nuanced interpretations of cross-sectional indices of the aging brain and question their validity as markers of ongoing within-person changes of the aging brain. Longitudinal imaging data should be preferred whenever the goal is to understand individual change trajectories of brain and cognition in aging.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

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