SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-31571"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-31571" > Polymorphisms in fa...

Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk.

Hoeft, Birgit, (författare)
German Cancer Research Center, Heidelberg, Germany
Linseisen, Jakob, (författare)
German Cancer Research Center, Heidelberg, Germany
Beckmann, Lars, (författare)
German Cancer Research Center, Heidelberg, Germany
visa fler...
Müller-Decker, Karin, (författare)
German Cancer Research Center, Heidelberg, Germany
Canzian, Federico, (författare)
German Cancer Research Center, Heidelberg, Germany
Hüsing, Anika, (författare)
German Cancer Research Center, Heidelberg, Germany
Kaaks, Rudolf, (författare)
German Cancer Research Center, Heidelberg, Germany
Vogel, Ulla, (författare)
National Food Institute, Technical University of Denmark, Soborg, Denmark, National Research Centre for the Working Environment, Copenhagen, Denmark
Jakobsen, Marianne Uhre, (författare)
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
Overvad, Kim, (författare)
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
Hansen, Rikke Dalgaard, (författare)
Danish Cancer Society, Copenhagen, Denmark
Knüppel, Sven, (författare)
Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
Boeing, Heiner, (författare)
Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
Trichopoulou, Antonia, (författare)
Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece, Hellenic Health Foundation, Greece
Yvoni, Koumantaki, (författare)
Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
Trichopoulos, Dimitrios, (författare)
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Berrino, Franco, (författare)
Etiological Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
Palli, Domenico, (författare)
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
Panico, Salvatore, (författare)
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Tumino, Rosario, (författare)
Cancer Registry and Histopathology Unit, Department of Oncology , “Civile - M.P.Arezzo” Hospital, Ragusa, Italy
Bueno-de-Mesquita, H Bas, (författare)
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
van Duijnhoven, Fränzel J B, (författare)
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
van Gils, Carla H, (författare)
Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
Peeters, Petra H, (författare)
Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands, Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
Dumeaux, Vanessa, (författare)
Institute of Community Medicine, University of Tromsø, Norway
Lund, Eiliv, (författare)
Institute of Community Medicine, University of Tromsø, Norway
Huerta Castaño, José M, (författare)
CIBER Epidemiología y Salud Pública, CIBERESP, Spain, Council of Health and Consumer Affairs, Murcia, Spain
Muñoz, Xavier, (författare)
Research Laboratory and Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain
Rodriguez, Laudina, (författare)
Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain
Barricarte, Aurelio, (författare)
CIBER Epidemiología y Salud Pública, CIBERESP, Spain, Public Health Institute of Navarra, Pamplona, Spain
Manjer, Jonas, (författare)
Department of Surgery, Malmö University Hospital, Malmö, Sweden
Jirström, Karin, (författare)
Center for Molecular Pathology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö Sweden, CREATE Health Center for Translational Cancer Research, Biomedical Center, Lund University, Lund, Sweden
Van Guelpen, Bethany, (författare)
Umeå universitet, Patologi
Hallmans, Göran, 1947- (författare)
Umeå universitet, Näringsforskning
Spencer, Elizabeth A, (författare)
Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Crowe, Francesca L, (författare)
Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Khaw, Kay-Tee, (författare)
Department of Public Health and Primary Care, University of Cambridge
Wareham, Nick, (författare)
Medical Research Council (MRC) Epidemiology Unit, Cambridge, UK
Morois, Sophie, (författare)
Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France
Boutron-Ruault, Marie-Christine, (författare)
Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France
Clavel-Chapelon, Françoise, (författare)
Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France
Chajes, Veronique, (författare)
International Agency for Research on Cancer (IARC), Lyon, France
Jenab, Mazda, (författare)
International Agency for Research on Cancer (IARC), Lyon, France
Boffetta, Paolo, (författare)
International Agency for Research on Cancer (IARC), Lyon, France
Vineis, Paolo, (författare)
Cancer Epidemiology Department, University of Turin, Turin, Italy, Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
Mouw, Traci, (författare)
Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
Norat, Teresa, (författare)
Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
Riboli, Elio, (författare)
Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
Nieters, Alexandra, (författare)
German Cancer Research Center, Heidelberg, Germany, Centre of Chronic Immunodeficiency, University of Freiburg Medical Centre, Freiburg, Germany
Mueller-Decker, Karin (författare)
Huesing, Anika (författare)
Knueppel, Sven (författare)
Koumantaki, Yvoni (författare)
Huerta Castano, Jose M. (författare)
Munoz, Xavier (författare)
visa färre...
Umeå universitet Medicinska fakulteten. Institutionen för medicinsk biovetenskap. Patologi. (creator_code:org_t)
Umeå universitet Medicinska fakulteten. Institutionen för folkhälsa och klinisk medicin. Näringsforskning. (creator_code:org_t)
visa fler...
Lunds universitet Kirurgi. (creator_code:org_t)
Lunds universitet Onkologi och Patologi, Kampradlab. (creator_code:org_t)
Lunds universitet EpiHealth: Epidemiology for Health. (creator_code:org_t)
visa färre...
2010
Engelska.
Ingår i: Carcinogenesis. - 0143-3334. ; 31:3, s. 466-472
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Colorectal cancer is the third most common malignant tumor and the fourth-leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. 392 single nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, HPGD, PLA2G6, and TRPV3 were associated with higher risk for colorectal cancer, while PTGER2 was associated with lower colorectal cancer risk. A significant inverse association (p < 0.006) was found for PTGER2 GGG haplotype while HPGD AGGAG and PLA2G3 CT haplotypes were significantly (p < 0.001 and p = 0.003, respectively) associated with higher risk of colorectal cancer. Based on these data we present for the first time the association of HPGD variants with colorectal cancer risk. Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and colorectal cancer risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy