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c-Met expression in primary tumors and their corresponding distant metastases

Isaksson-Mettävainio, Martin (författare)
Umeå universitet,Patologi
Van Guelpen, Bethany (författare)
Umeå universitet,Patologi
Öberg, Åke (författare)
Umeå universitet,Patologi
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Stenling, Roger (författare)
Umeå universitet,Patologi
Palmqvist, Richard (författare)
Umeå universitet,Patologi
Henriksson, Maria L (författare)
Umeå universitet,Patologi
visa färre...
 (creator_code:org_t)
Umeå, 2009
2009
Engelska.
Ingår i: Molecular Medicine Reports. - Umeå. - 1791-2997. ; 1:6, s. 787-790
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • c-Met is a receptor tyrosine kinase that has beenimplicated in the pathogenesis and growth of a wide variety ofhuman malignancies, including CRC, but its role in metastasisis largely unknown. We compared c-Met expression in primaryhuman colorectal carcinomas and distant metastases from thesame patients. Formalin-fixed paraffin-embedded tissuesamples from 69 colorectal cancer patients were obtained. Theprotein expression of c-Met was evaluated immunohistochemicallyusing a commercial antibody. The difference inexpression between primary tumors and their correspondingdistant metastases was analyzed using the Wilcoxon signedranktest. c-Met expression was statistically significantlylower in the distant metastases compared to their correspondingprimary tumors (p<0.001), whereas no difference was foundbetween lymph node metastases and their correspondingprimary tumors (p=0.957). The degree of c-Met expressionwas not related to clinicopathological characteristics such astumor grade and Dukes' stage at the time of primary tumordiagnosis, or to the location of the distant metastases. Wedemonstrated that c-Met expression is often reduced in distantmetastases compared to their corresponding primary colorectaltumors. Additional studies of c-Met activation and signaltransduction will increase our knowledge about the role ofc-Met in colorectal cancer metastasis.

Nyckelord

c-Met
colorectal cancer
metastasis
MEDICINE
MEDICIN

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