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Sökning: onr:"swepub:oai:DiVA.org:umu-46219" > Comprehensive analy...

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

Kharchenko, Peter V (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
Alekseyenko, Artyom A (författare)
Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Schwartz, Yuri B (författare)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
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Minoda, Aki (författare)
Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA
Riddle, Nicole C (författare)
Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
Ernst, Jason (författare)
MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA,Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Sabo, Peter J (författare)
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Larschan, Erica (författare)
Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02906, USA
Gorchakov, Andrey A (författare)
Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Gu, Tingting (författare)
Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
Linder-Basso, Daniela (författare)
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
Plachetka, Annette (författare)
Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Shanower, Gregory (författare)
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
Tolstorukov, Michael Y (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
Luquette, Lovelace J (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
Xi, Ruibin (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
Jung, Youngsook L (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
Park, Richard W (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA
Bishop, Eric P (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA
Canfield, Theresa K (författare)
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Sandstrom, Richard (författare)
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Thurman, Robert E (författare)
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
MacAlpine, David M (författare)
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Stamatoyannopoulos, John A (författare)
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA,Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Kellis, Manolis (författare)
MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA,Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Elgin, Sarah C R (författare)
Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
Kuroda, Mitzi I (författare)
Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Pirrotta, Vincenzo (författare)
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
Karpen, Gary H (författare)
Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA
Park, Peter J (författare)
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA and Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
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 (creator_code:org_t)
2011
2011
Engelska.
Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 471:7339, s. 480-485
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.

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