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Sökning: onr:"swepub:oai:DiVA.org:umu-48642" > Type IV collagen as...

Type IV collagen as a tumour marker for colorectal liver metastases

Nyström, Hanna, 1980- (författare)
Umeå universitet, Kirurgi, Malin Sund
Naredi, Peter, 1955- (författare)
Umeå universitet, Kirurgi
Hafström, Larsolof (författare)
visa fler...
Sund, Malin, 1972- (författare)
Umeå universitet, Kirurgi, Malin Sund
visa färre...
2011
Engelska.
Ingår i: European Journal of Surgical Oncology. - Elsevier. - 0748-7983 .- 1532-2157. ; 37:7, s. 611-617
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p><strong>BACKGROUND:</strong> About 50% of patients with primary colorectal cancer (CRC) will develop liver metastases (CLM). Currently, carcinoembryonic antigen (CEA) is the most common tumour marker for CRC and CLM. However, the sensitivity and specificity of this marker is not optimal, as almost 50% of patients have tumours that do not produce CEA. Therefore there is a need for better markers for CRC and CLM.</p><p><strong>METHODS:</strong> The circulating levels of type IV collagen were measured in patients with CLM, primary CRC and in healthy controls. The expression pattern of type IV collagen was studied by immunofluorescence in CLM and normal liver tissue. The metastatic volume of CLM in the liver was estimated from CT.</p><p><strong>RESULTS:</strong> In CLM tissue type IV collagen is highly expressed in the areas of desmoplasia. Patients with primary CRC (Dukes' A-C) did not show any increase in circulating type IV collagen compared to healthy controls. However, patients with CLM have significantly elevated levels of circulating type IV collagen when compared to patients with primary CRC and healthy controls. The levels of type IV collagen decreased during chemotherapy and increased at the time of disease progression. The circulating levels of type IV collagen seem to reflect the tumour burden in the liver.</p><p><strong>CONCLUSIONS:</strong> Type IV collagen has the potential to be used as tumour associated biomarker for CLM. These results indicate the importance of interaction between cancer cells and the stroma in the tumour microenvironment.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

Collagen
Basement membrane
Stroma
Biomarker
Cancer
MEDICINE Surgery
MEDICIN Kirurgi

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Nyström, Hanna, ...
Naredi, Peter, 1 ...
Hafström, Larsol ...
Sund, Malin, 197 ...
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MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Kirurgi
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Umeå universitet

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