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LIBRIS Formathandbok  (Information om MARC21)
00005479naa a22007693a 4500
008080901s2012 xx |||| |0|| 0|eng d
024a 10.1093/carcin/bgs1332 doi
024a 224317192 pmid
024a 0003061358000122 isi
024a urn:nbn:se:umu:diva-535022 urn
040 a (SwePub)umu
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Aleksandrova, Krasimira4 aut0 (SwePub:)
2451 0a Total and high-molecular-weight adiponectin and risk of colorectal cancer :b the European prospective investigation into cancer and nutrition study
500 a 40
500 a Published
5208 enga Adiponectin - an adipose-tissue-derived protein may provide a molecular link between obesity and colorectal cancer (CRC), but evidence from large prospective studies is limited. In particular, no epidemiological study explored high-molecular-weight (HMW) and non-HMW adiponectin fractions in relation to CRC risk, despite they were hypothesised to have differential biological activities, i.e. regulating insulin sensitivity (HMW-adiponectin) versus inflammatory response (non-HMW-adiponectin). In a prospective nested case-control study we investigated whether pre-diagnostic serum concentrations of total, HMW and non-HMW-adiponectin are associated with risk of CRC, independent of obesity and other known CRC risk factors. A total of 1206 incident cases (755 colon, 451 rectal) were matched to 1206 controls using incidence density sampling. In conditional logistic regression, adjusted for dietary and lifestyle factors, total adiponectin and non-HMW-adiponectin concentrations were inversely associated with risk of CRC [relative risk (RR) comparing highest versus lowest quintile = 0.71, 95% confidence interval (CI) = 0.53-0.95, P (trend)=0.03 for total adiponectin and 0.45, 95%CI=0.34-0.61, P (trend)<0.0001 for non-HMW-adiponectin]. HMW-adiponectin concentrations were not associated with CRC risk (RR=0.91, 95%CI=0.68-1.22, P (trend)=0.55). Non-HMW-adiponectin was associated with CRC risk even after adjustment for body mass index and waist circumference (RR=0.39, 95%CI=0.26-0.60, P (trend)<0.0001); whereas the association with total adiponectin was no longer significant (RR=0.81, 95%CI=0.60-1.09, P (trend)=0.23). When stratified by cancer site, non-HMW-adiponectin was inversely associated with both colon and rectal cancer. These findings suggest an important role of the relative proportion of non-HMW-adiponectin in CRC pathogenesis. Future studies are warranted to confirm these results and to elucidate the underlying mechanisms.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi2 hsv//swe0 (SwePub)30203
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology2 hsv//eng0 (SwePub)30203
700a Boeing, Heiner4 aut0 (SwePub:)
700a Jenab, Mazda4 aut0 (SwePub:)
700a Bueno-de-Mesquita, H Bas4 aut0 (SwePub:)
700a Jansen, Eugene4 aut0 (SwePub:)
700a van Duijnhoven, Fränzel JB4 aut0 (SwePub:)
700a Fedirko, Veronika4 aut0 (SwePub:)
700a Rinaldi, Sabina4 aut0 (SwePub:)
700a Romieu, Isabelle4 aut0 (SwePub:)
700a Riboli, Elio4 aut0 (SwePub:)
700a Romaguera, Dora4 aut0 (SwePub:)
700a Westphal, Sabine4 aut0 (SwePub:)
700a Overvad, Kim4 aut0 (SwePub:)
700a Tjønneland, Anne4 aut0 (SwePub:)
700a Boutron-Ruault, Marie Christine4 aut0 (SwePub:)
700a Clavel-Chapelon, Françoise4 aut0 (SwePub:)
700a Kaaks, Rudolf4 aut0 (SwePub:)
700a Lukanova, Annekatrin4 aut0 (SwePub:)
700a Trichopoulou, Antonia4 aut0 (SwePub:)
700a Lagiou, Pagona4 aut0 (SwePub:)
700a Trichopoulos, Dimitrios4 aut0 (SwePub:)
700a Agnoli, Claudia4 aut0 (SwePub:)
700a Mattiello, Amalia4 aut0 (SwePub:)
700a Saieva, Calogero4 aut0 (SwePub:)
700a Vineis, Paolo4 aut0 (SwePub:)
700a Tumino, Rosario4 aut0 (SwePub:)
700a Peeters, Petra H4 aut0 (SwePub:)
700a Argüelles, Marcial4 aut0 (SwePub:)
700a Bonet, Catalina4 aut0 (SwePub:)
700a Sánchez, María-José4 aut0 (SwePub:)
700a Dorronsoro, Miren4 aut0 (SwePub:)
700a Huerta, Jose-María4 aut0 (SwePub:)
700a Barricarte, Aurelio4 aut0 (SwePub:)
700a Palmqvist, Richard,u Umeå universitet, Patologi4 aut0 (SwePub:umu)ripa0001
700a Hallmans, Göran,u Umeå universitet, Näringsforskning4 aut0 (SwePub:umu)goha0001
700a Khaw, Kay-Tee4 aut0 (SwePub:)
700a Wareham, Nick4 aut0 (SwePub:)
700a Allen, Naomi E4 aut0 (SwePub:)
700a Crowe, Francesca L4 aut0 (SwePub:)
700a Pischon, Tobias4 aut0 (SwePub:)
710a Umeå universitet.b Medicinska fakulteten.b Institutionen för medicinsk biovetenskap.b Patologi.4 org0 (SwePub:umu)749
710a Umeå universitet.b Medicinska fakulteten.b Institutionen för folkhälsa och klinisk medicin.b Näringsforskning.4 org0 (SwePub:umu)731
773t Carcinogenesisx 0143-3334g 33:6, s. 1211-1218q 33:6<1211-1218
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53502y Till lärosätets (umu) databasx lärosäteslänk
8564 8u http://dx.doi.org/10.1093/carcin/bgs133

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