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Sökning: onr:"swepub:oai:DiVA.org:umu-5767" > Polymorphisms in th...

Polymorphisms in the genes of the urokinase plasminogen activation system in relation to colorectal cancer

Försti, A (författare)
Lei, H (författare)
Tavelin, Björn (författare)
Norrlands University Hospital
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Enquist, K (författare)
Umeå universitet,Näringsforskning
Palmqvist, Richard (författare)
Umeå universitet,Patologi
Altieri, A (författare)
Hallmans, Göran, 1947- (författare)
Umeå universitet,Näringsforskning
Hemminki, K (författare)
Lenner, Per (författare)
Norrlands University Hospital
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 (creator_code:org_t)
Oxford University Press, 2007
2007
Engelska.
Ingår i: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 18:12, s. 1990-1994
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Extracellular matrix degradation, mediated by the urokinase plasminogen activation (uPA) system, is a critical step in tumor invasion and metastasis. High tumor levels of uPA and its inhibitor PAI-1 have been correlated with poor cancer prognosis. We examined four single nucleotide polymorphisms (SNPs) with a potential effect on expression of genes in the uPA system for their role in colorectal cancer susceptibility and prognosis.Patients and methods: We genotyped the SNPs in 308 Swedish incident colorectal cancer patients with up to 16 years of follow-up and in 585 age- and sex-matched controls. We evaluated the associations between genotypes and colorectal cancer and Dukes' stage. Survival probabilities were compared between different subgroups.Results: Patients with PAI-1 –675 5G/5G genotype had better survival than patients with 4G/4G or 4G/5G genotypes when they had Dukes' stage A or B tumors (P = 0.023 and P = 0.015, respectively). No statistically significant association was observed between the SNPs and the risk of colorectal cancer or Dukes' stage.Conclusions: Our results suggest a role for the PAI-1 genotype in colorectal cancer prognosis, but further studies are needed to evaluate the impact of our finding in the clinic.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

colorectal cancer
PAI-1
prognostic biomarker
single nucleotide polymorphism
uPA system

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