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Sökning: onr:"swepub:oai:DiVA.org:uu-111078" > <em>LPL</em> is the...

<em>LPL</em> is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia

Kaderi, Mohd Arifin, (författare)
Uppsala universitet, Hematologi och immunologi, Molecular Haematology
Kanduri, Meena, (författare)
Uppsala universitet, Hematologi och immunologi, Molecular Haematology
Buhl, Anne Mette, (författare)
Department of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
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Sevov, Marie, (författare)
Uppsala universitet, Hematologi och immunologi, Molecular Haematology
Cahill, Nicola, (författare)
Uppsala universitet, Hematologi och immunologi, Molecular Haematology
Gunnarsson, Rebeqa, (författare)
Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden
Jansson, Mattias, (författare)
Uppsala universitet, Hematologi och immunologi
Ekström Smedby, Karin, (författare)
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
Hjalgrim, Hendrik, (författare)
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Juliusson, Gunnar, (författare)
Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden
Jurlander, Jesper, (författare)
Department of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
Mansouri, Larry, (författare)
Uppsala universitet, Hematologi och immunologi, Molecular Haematology
Rosenquist, Richard, (författare)
Uppsala universitet, Hematologi och immunologi, Molecular Haematology
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2011
Engelska.
Ingår i: Haematologica (online). - 0390-6078 .- 1592-8721. ; 96:8, s. 1153-1160
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • <p><strong>BACKGROUND:</strong></p> <p>The expression levels of LPL, ZAP70, TCL1A, CLLU1 and MCL1 have recently been proposed as prognostic factors in chronic lymphocytic leukemia. However, few studies have systematically compared these different RNA-based markers.</p> <p><strong>DESIGN AND METHODS:</strong></p> <p>Using real-time quantitative PCR, we measured the mRNA expression levels of these genes in unsorted samples from 252 newly diagnosed chronic lymphocytic leukemia patients and correlated our data with established prognostic markers (for example Binet stage, CD38, IGHV gene mutational status and genomic aberrations) and clinical outcome.</p> <p><strong>RESULTS:</strong></p> <p>High expression levels of all RNA-based markers, except MCL1, predicted shorter overall survival and time to treatment, with LPL being the most significant. In multivariate analysis including the RNA-based markers, LPL expression was the only independent prognostic marker for overall survival and time to treatment. When studying LPL expression and the established markers, LPL expression retained its independent prognostic strength for overall survival. All of the RNA-based markers, albeit with varying ability, added prognostic information to established markers, with LPL expression giving the most significant results. Notably, high LPL expression predicted a worse outcome in good-prognosis subgroups, such as patients with mutated IGHV genes, Binet stage A, CD38 negativity or favorable cytogenetics. In particular, the combination of LPL expression and CD38 could further stratify Binet stage A patients.</p> <p><strong>CONCLUSIONS:</strong></p> <p>LPL expression is the strongest RNA-based prognostic marker in chronic lymphocytic leukemia that could potentially be applied to predict outcome in the clinical setting, particularly in the large group of patients with favorable prognosis.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

MEDICINE
MEDICIN
MEDICINE Dermatology and venerology,clinical genetics, internal medicine Clinical genetics
MEDICIN Dermatologi och venerologi, klinisk genetik, invärtesmedicin Klinisk genetik
MEDICINE Surgery Oncology
MEDICIN Kirurgi Onkologi
Clinical Genetics
Klinisk genetik
Medical Genetics
Medicinsk genetik
Oncology
Onkologi

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