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Sökning: onr:"swepub:oai:DiVA.org:uu-11837" > Lack of an associat...

Lack of an association between the TGFBR1*6A variant and colorectal cancer risk

Skoglund, Johanna (författare)
Song, Bo (författare)
Dalén, Johan (författare)
visa fler...
Dedorson, Stefan (författare)
Edler, David (författare)
Hjern, Fredrik (författare)
Holm, Jörn (författare)
Lenander, Claes (författare)
Lindforss, Ulrik (författare)
Lundqvist, Nils (författare)
Olivecrona, Hans (författare)
Olsson, Louise (författare)
Påhlman, Lars, (författare)
Uppsala universitet, Kolorektalkirurgi
Rutegård, Jörgen (författare)
Smedh, Kennet, (författare)
Uppsala universitet, Centrum för klinisk forskning, Västerås
Törnqvist, Anders (författare)
Houlston, Richard S. (författare)
Lindblom, Annika (författare)
visa färre...
2007
Engelska.
Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 13:12, s. 3748-3752
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p><strong>Purpose:</strong> Recently a common variant of the <em>TGFBR1</em> gene, <em>TGFBR1</em>*6A, has been proposed to act as a low-penetrance tumor susceptibility allele for colorectal cancer, but data from published studies with individually low statistical power are conflicting. To further evaluate the relationship between <em>TGFBR1</em>*6A and colorectal cancer risk, we have conducted a large case-control study and a meta-analysis of previously published studies.</p> <p><strong>Experimental Design:</strong> A total of 1,042 colorectal cancer cases and 856 population controls were genotyped for the <em>TGFBR1</em>*6A polymorphism. Previously published case-control studies of the relationship between <em>TGFBR1</em>*6A and colorectal cancer were identified, and a meta-analysis was conducted.</p> <p><strong>Results:</strong> We found no evidence that homozygosity, heterozygosity or carrier status for the <em>TGFBR1</em>*6A allele confers an increased risk of colorectal cancer; respective odds ratios (OR) were 1.05 [95% confidence interval (95% CI), 0.83-1.32], 0.82 (95% CI, 0.34-1.99), and 0.92 (95% CI, 0.74-1.15), respectively. A meta-analysis of our case-control study and seven other studies that provided data on 2,627 colorectal cancer cases and 3,387 controls also yielded no evidence that possession of the <em>TGFBR1</em>*6A allele is associated with an elevated risk of colorectal cancer; pooled estimate of the OR were 1.20 (95% CI, 0.64-2.24) for homozygosity, 1.11 (95% CI, 0.96-1.29) for heterozygosity, and 1.13 (95% CI, 0.98-1.30) for carriers of <em>TGFBR1</em>*6A.</p> <p><strong>Conclusion:</strong> Current data provide limited support for the hypothesis that sequence variation in <em>TGFBR1</em> defined by the <em>TGFBR1</em>*6A allele confers an elevated risk of colorectal cancer.</p>

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MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

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MEDICINE
MEDICIN

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