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Inverse association of leptin levels with renal cell carcinoma : results from a case-control study

Spyridopoulos, Themistoklis N. (författare)
Petridou, Eleni Th. (författare)
Dessypris, Nick (författare)
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Terzidis, Agapios (författare)
Skalkidou, Alkistis, (författare)
Uppsala universitet, Institutionen för kvinnors och barns hälsa, Reproduktiv hälsa/Sundström Poromaa
Deliveliotis, Charalambos (författare)
Chrousos, George P. (författare)
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2009
Engelska.
Ingår i: Hormones (Athens, Greece). - 1109-3099. ; 8:1, s. 39-46
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity. Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk. DESIGN: This case-control study included 70 patients with newly diagnosed, histologically confirmed RCC and 280 age-, gender- and district of residence-matched controls. Anthropometric data, socio-demographic variables, medical history, lifestyle habits and dietary data were derived from a personal interview. Serum leptin and adiponectin levels were determined using standard commercial kits. Adjusted odds ratios for RCC risk were derived through multiple logistic regression analyses. RESULTS: Leptin levels were inversely associated with RCC risk (OR: 0.53, CI: 0.28- 0.99, p = 0.05), even after controlling for potential confounding factors, such as Body Mass Index (BMI), recent weight change, history of diabetes mellitus and other obesity related hormones, notably adiponectin. CONCLUSIONS: The precise mechanism linking obesity with RCC remains unclear; however, the inverse association of leptin with RCC might be attributed, at least in part, to hormonal cross-talk with complex neuron-endocrine and immune circuits. These findings, if confirmed in prospective and interventional studies, might further elucidate the underlying mechanisms.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

Adiponectin
Immunity
Inflammation
Leptin
Obesity
Renal cell carcinoma
MEDICINE
MEDICIN

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