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Sökning: onr:"swepub:oai:DiVA.org:uu-125821" > Adjuvant tamoxifen ...

Adjuvant tamoxifen in breast cancer patients affects the endometrium by time, an effect remaining years after end of treatment and results in an increased frequency of endometrial carcinoma

Lindahl, Bengt (författare)
Andolf, Ellika (författare)
Ingvar, Christian (författare)
visa fler...
Ranstam, Jonas (författare)
Willén, Roger, (författare)
Uppsala universitet, Institutionen för genetik och patologi
visa färre...
2008
Engelska.
Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 28:2B, s. 1259-1262
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>Tamoxifen is the most used adjuvant drug in breast cancer treatment. Its main action is as an anti-oestrogen, but in the endometrium of some patients it acts as an oestrogen. Some investigators have even reported an increased risk of developing endometrial carcinoma. The question of how to follow-up these patients and how to identify patients at risk of developing endometrial premalignant changes was investigated by the noninvasive ultrasound method. The follow-up of 292 patients from before the start of adjuvant treatment with tamoxifen and 94 without tamoxifen treatment was conducted at regular intervals. The changes in endometrial thickness as measured by ultrasound and histopathological changes are reported. A thicker endometrium was found in patients with receptor positive breast cancer even before the treatment with tamoxifen started. Cumulative increasing thickness was found during treatment and this thicker endometrium remained until almost 3 years after the end of treatment. If the endometrium was &lt;3 mm after 3 months of treatment the probability that it would be thin after 5 years was high. An increased risk of developing endometrial carcinoma was found, however due to this regular follow-up the cancer was identified at an early stage.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Tamofixen
breat cancer
endometiral carcinoma
MEDICINE Surgery Obstetrics and women's diseases Obstetrics and gynaecology
MEDICIN Kirurgi Obstetrik och kvinnosjukdomar Obstetrik och gynekologi
MEDICINE Morphology, cell biology, pathology Pathology
MEDICIN Morfologi, cellbiologi, patologi Patologi
Pathology
Patologi
Obstetrik och gynekologi
Obstetrics and Gynaecology

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