Sökning: onr:"swepub:oai:DiVA.org:uu-134998" >
IgE to peanut aller...
IgE to peanut allergen components : relation to peanut symptoms and pollen sensitization in 8-year-olds
-
- Asarnoj, A. (författare)
- Karolinska Institutet
-
- Movérare, Robert (författare)
- Uppsala universitet,Lungmedicin och allergologi
-
- Östblom, E. (författare)
- Karolinska Institutet
-
visa fler...
-
Poorafshar, M. (författare)
-
- Lilja, G. (författare)
- Karolinska Institutet
-
- Hedlin, G. (författare)
- Karolinska Institutet
-
- van Hage, M. (författare)
- Karolinska Institutet
-
- Ahlstedt, S. (författare)
- Karolinska Institutet
-
- Wickman, M. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Wiley, 2010
- 2010
- Engelska.
-
Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 65:9, s. 1189-1195
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Allergen-specific IgE testing is often performed with crude peanut extract, but the results may be difficult to interpret because of cross-reactions between peanut and other plant allergens. The aim was to investigate IgE reactivity to peanut allergen components in children from a birch-rich region in relation to pollen sensitization and peanut symptoms. Methods: From a birth cohort, clinical parameters were obtained through questionnaires and IgE antibody levels to peanut and birch pollen were measured. Different peanut/birch sensitization phenotypes were defined among 200 selected children. IgE reactivity to peanut and pollen allergen components was analysed using microarray technique. Results: Peanut symptoms were reported in 87% of the children with IgE reactivity to any of the peanut allergens Ara h 1, 2 or 3 but not to Ara h 8 (n = 46) vs 17% of children with IgE reactivity to Ara h 8 but not to Ara h 1, 2 or 3 (n = 23), P < 0.001. Furthermore, symptoms were more severe in children with Ara h 1, 2 or 3 reactivity. Children with IgE reactivity both to Ara h 2 and to Ara h 1 or 3 more often reported peanut symptoms than children with IgE only to Ara h 2 (97% vs 70%, P = 0.016), particularly respiratory symptoms (50% vs 9%, P = 0.002). Conclusions: IgE analysis to peanut allergen components may be used to distinguish between peanut-sensitized individuals at risk of severe symptoms and those likely to have milder or no symptoms to peanut if sensitized to pollen allergens and their peanut homologue allergens.
Nyckelord
- allergen components
- BAMSE
- childhood
- IgE
- peanut
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas