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Sökning: onr:"swepub:oai:DiVA.org:uu-147270" > Phase II trial of z...

Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma

d'Amore, Francesco (författare)
Radford, John (författare)
Relander, Thomas (författare)
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Jerkeman, Mats (författare)
Tilly, Herve (författare)
Österborg, Anders (författare)
Morschhauser, Franck (författare)
Gramatzki, Martin (författare)
Dreyling, Martin (författare)
Bang, Bo (författare)
Hagberg, Hans, (författare)
Uppsala universitet, Enheten för onkologi
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2010
Engelska.
Ingår i: British Journal of Haematology. - 0007-1048 .- 1365-2141. ; 150:5, s. 565-573
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>The efficacy and safety of zanolimumab (HuMax-CD4) in patients with relapsed or refractory peripheral T Cell lymphoma (PTCL) was evaluated. Twenty-one adult patients with relapsed or refractory CD4+ PTCL of non-cutaneous type (angioimmunoblastic T cell lymphoma (AITL) n = 9, PTCL-not otherwise specified (NOS) n = 7, anaplastic large cell lymphoma (ALCL) n = 4 and enteropathy type T cell lymphoma n = 1) were treated in a single-arm multi-centre study, with weekly intravenous infusions of zanolimumab 980 mg for 12 weeks. Median age was 69 years (range 26-85). Seventeen of the patients had advanced stage disease (Ann Arbor stages III-IV). Objective tumour responses were obtained in 24% of the patients with two complete responses unconfirmed (CRu) and three partial responses (PR). One of the CRus lasted more than 252 d. Responses were obtained in different PTCL entities: AITL (n = 3), ALCL (n = 1) and PTCL-NOS (n = 1). In general, the trial drug was well tolerated with no major toxicity. Zanolimumab at a dose of 980 mg weekly demonstrated clinical activity and an acceptable safety profile in this poor-prognosis patient population, suggesting that the potential benefit combining zanolimumab with standard chemotherapy in the treatment of PTCL should be investigated.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

peripheral T cell lymphoma
CD4
angioimmunoblastic
anaplastic
zanolimumab
MEDICINE
MEDICIN

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