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Swedish Lung Cancer...
Swedish Lung Cancer Radiation Study Group: Predictive value of histology for radiotherapy response in patients with non-small cell lung cancer
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- Holgersson, Georg (författare)
- Uppsala universitet,Enheten för onkologi,University of Uppsala Hospital,Centrum för klinisk forskning, Gävleborg
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- Bergström, Stefan (författare)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Gävle Central Hospital
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- Bergqvist, Michael (författare)
- Uppsala universitet,Enheten för onkologi,University of Uppsala Hospital,Centrum för klinisk forskning, Gävleborg
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- Nyman, Jan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens University Hospital
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- Hoye, Even (författare)
- Gävle Central Hospital
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- Helsing, Martin (författare)
- Örebro University Hospital
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- Friesland, Signe (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Holgersson, Margareta (författare)
- Uppsala universitet,Enheten för onkologi,University of Uppsala Hospital
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- Birath, Elisabet (författare)
- Skåne University Hospital
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- Ekman, Simon (författare)
- Uppsala universitet,Enheten för onkologi,University of Uppsala Hospital
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- Blystad, Thomas (författare)
- Östergötlands Läns Landsting,Lungmedicinska kliniken US
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- Ewers, Sven-Börje (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Lund Hospital
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- Morth, Charlotte (författare)
- Malar Hospital
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- Loden, Britta (författare)
- Central Hospital Karlstad
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- Henriksson, Roger (författare)
- Umeå universitet,Onkologi
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 47:16, s. 2415-2421
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Abstract
Ämnesord
Stäng
- The aim of the present study was to evaluate the potential predictive value of histology in non-small cell lung cancer (NSCLC) treated with curatively intended radiotherapy. In a collaborative effort among all the Swedish Oncology Departments, clinical data were collected for 1146 patients with a diagnosed non-small cell lung cancer subjected to curatively intended irradiation (>= 50 Gy) during the years 1990 to 2000. The included patients were identified based on a manual search of all medical and radiation charts at the oncology departments from which the individual patient data were collected. Only patients who did not have a histological diagnosis date and death date/last follow-up date were excluded (n = 141). Among the 1146 patients with non-small cell carcinoma eligible for analysis, 919 were diagnosed with either adenocarcinoma (n = 323) or squamous cell carcinoma (n = 596) and included in this study. The median survival for the 919 patients was 14.8 months, while the 5-year survival rate was 9.5%. Patients with adenocarcinoma had a significantly better overall survival compared with patients with squamous cell carcinoma (p = 0.0062, log-rank test). When comparing different stages, this survival benefit was most pronounced for stages IIA-IIB (p<0.0001, log-rank test). The difference in survival between the two histological groups was statistically significant in a univariate Cox analysis (p = 0.0063) as well as in two multivariate Cox analyses including demographic and treatment variables (p = 0.037 and p = 0.048, respectively). In this large population based retrospective study we describe for the first time that patients with adenocarcinoma have a better survival after curatively intended radiation therapy in comparison with squamous cell carcinoma patients, particularly those with clinical stages IIA-IIB. (C) 2011 Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Lung cancer
- Non-small cell lung cancer
- Histology
- Predictive value
- Adenocarcinoma
- Squamous cell carcinoma
- Lung cancer
- TECHNOLOGY
- Oncology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Holgersson, Geor ...
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Bergström, Stefa ...
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Bergqvist, Micha ...
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Nyman, Jan, 1956
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Hoye, Even
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Helsing, Martin
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Friesland, Signe
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Holgersson, Marg ...
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Birath, Elisabet
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Ekman, Simon
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Blystad, Thomas
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Ewers, Sven-Börj ...
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Morth, Charlotte
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Loden, Britta
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Henriksson, Roge ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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European Journal ...
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Lunds universitet
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Göteborgs universitet
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Karolinska Institutet
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Uppsala universitet
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Linköpings universitet
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Umeå universitet
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