SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-170695"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-170695" > The risk of myocard...

The risk of myocardial infarction is enhanced by a synergistic interaction between serum insulin and smoking.

Bennet, Anna M (författare)
Brismar, Kerstin (författare)
Hallqvist, Johan, 1950- (författare)
Uppsala universitet,Medicinska och farmaceutiska vetenskapsområdet,Preventivmedicin
visa fler...
Reuterwall, Christina (författare)
De Faire, Ulf (författare)
Bennet, AM (författare)
Karolinska Institutet
Brismar, K (författare)
Karolinska Institutet
Reuterwall, C (författare)
de Faire, U (författare)
Karolinska Institutet
Hallqvist, J (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
2002
2002
Engelska.
Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 147:5, s. 641-7
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVES: To evaluate the relationship between levels of serum insulin, the homeostasis model assessment (HOMA) and IGF-binding protein-1 (IGFBP-1) as factors related to myocardial infarction (MI) risk, and their interaction with lifestyle-related risk factors. DESIGN: The Stockholm epidemiology programme (SHEEP), a case-control study, consisting of 749 first-time MI cases (510 men, 239 women) and 1101 healthy controls (705 men, 396 women) was used. METHODS: The risk of developing MI was assessed by calculating odds ratios (OR) and synergistic interactions (SI) between serum insulin, IGFBP-1, HOMA and other variables related to MI risk (including smoking) in men and women. RESULTS: Subjects with elevated levels of insulin and HOMA (>75th percentile) had increased MI risks when compared with individuals with low levels. ORs for elevated insulin and HOMA (adjusted for age and residential area) for men: insulin 1.6 (95% confidence interval (CI) 1.3-2.1) and HOMA 1.5 (95% CI 1.1-1.9) and for women: insulin 2.1 (95% CI 1.5-2.9) and HOMA 1.9 (95% CI 1.3-2.8). Women with low levels of IGFBP-1 (<10th percentile) showed a tendency towards elevated MI risk even if this was not statistically significant (OR 1.5 (95% CI 0.9-2.6)). Smokers with high levels of serum insulin had greatly increased MI risk (OR for men: 4.7 (95% CI 3.0-7.2) and OR for women: 8.1 (95% CI 4.5-14.8)). SI scores based upon these interactions were statistically significant. CONCLUSIONS: These results might have preventive cardiovascular implications as they clearly suggest that subjects with insulin resistance are particularly susceptible to the hazards of smoking.

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy