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Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact

Nilsson, Cecilia, (författare)
Uppsala universitet, Centrum för klinisk forskning, Västerås, Uppsala universitet, Enheten för onkologi
Johansson, Ida, (författare)
Department of Oncology, Clinical Sciences and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund
Ahlin, Cecilia, (författare)
Department of Oncology, Örebro University Hospital, Örebro, Sweden
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Thorstenson, Sten, (författare)
Department of Pathology, Linköping University Hospital, Linköping, Sweden
Amini, Rose-Marie, (författare)
Uppsala universitet, Molekylär och morfologisk patologi
Holmqvist, Marit, (författare)
Uppsala-Örebro Regional Oncologic Center, Uppsala, Sweden
Bergkvist, Leif, (författare)
Uppsala universitet, Centrum för klinisk forskning, Västerås
Hedenfalk, Ingrid, (författare)
Department of Oncology, Clinical Sciences and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
Fjällskog, Marie-Louise, (författare)
Uppsala universitet, Enheten för onkologi
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 52:1, s. 102-109
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • <p><strong>Background. </strong></p><p>Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters.</p><p><strong>Material and methods.</strong></p><p>In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and histological grading on conventional slides. Cox proportional regression models were applied for uni- and multivariate analyses using breast cancer death as the event.</p><p><strong>Results. </strong></p><p>Estrogen receptor (ER) and progesterone receptor positivity were demonstrated in 93% and 77% of patients, respectively. Nottingham histologic grade (NHG) III was seen in 41% and HER2 positivity in 11%. Classification into molecular subtypes using IHC markers according to three alternative definitions revealed luminal A and luminal B in 81% vs. 11%; 48% vs. 44% and 41% vs. 42% of cases. Two cases of basal-like were identified, but no cases of HER2-like. Factors associated with an increased risk of breast cancer death were node positivity (HR 4.5; 95% CI 1.8-11.1), tumor size &gt; 20 mm (HR 3.3; 95% CI 1.4-7.9) and ER negativity (HR 10.9; 95% CI 3.2-37.9). No difference in breast cancer death between the luminal subgroups was demonstrated, regardless of definition.</p><p><strong>Conclusion.</strong></p><p>MBC tumors were more often of high grade, whereas HER2 overexpression was as frequent as in FBC. Lymph nodes, tumor size and ER status were independent predictors of breast cancer death. The prognostic impact of molecular subtyping in MBC seems to differ from that previously established in FBC.</p>


MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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