SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-17800"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-17800" > Aquaporin 1 is expr...

Aquaporin 1 is expressed in the human endometrium during normal cycle and increases after mifepristone treatment.

Hildenbrand, Anna (författare)
Stavreus-Evers, Anneli (författare)
Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
Lalitkumar, P G L (författare)
visa fler...
Nielsen, Soren (författare)
Mints, Miriam (författare)
Gemzell-Danielsson, Kristina (författare)
Nielsen, S (författare)
Mints, M (författare)
Karolinska Institutet
Lalitkumar, PGL (författare)
Karolinska Institutet
Gemzell-Danielsson, K (författare)
Karolinska Institutet
Hildenbrand, A (författare)
Karolinska Institutet
Stavreus-Evers, A (författare)
visa färre...
 (creator_code:org_t)
2008
2008
Engelska.
Ingår i: International Journal of Molecular Medicine. - 1107-3756 .- 1791-244X. ; 22:1, s. 49-53
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aquaporin-1 (AQP1) is involved in the angiogenesis and structural modifications of microvessels and possibly also in the pathogenesis of idiopathic menhorrhagia, where a reduced AQP1 expression is seen in the endometrium. Mifepristone treatment induces reduced menstrual bleeding and amenorrhea and also has a direct effect on endometrial arterioles. Administered with gestagen-only contraceptive methods, antiprogestins improve the bleeding pattern. The objective of this study was to evaluate the AQP1 expression in endometrial blood vessels during normal cycle and after mifepristone treatment. Localization and expression of AQP1 was determined using immunohistochemistry and reverse transcriptase chain reaction (RT-PCR) in 43 biopsies from human endometrium taken during a normal cycle and after mifepristone treatment. AQP1 expression in human endometrial vessels is not cycle dependent and is stronger in capillaries and arteries than in veins. After mifepristone treatment the staining intensity was increased, but not the number of stained vessels. The presence of AQP1 was also confirmed using RT-PCR. The changes in AQP1 expression could contribute to the reduced bleeding seen following mifepristone treatment and could be an effect of either antagonizing progesterone or cortisol.

Nyckelord

aquaporin-1
endometrium
water channel
milepristone
angiogenesis
MEDICINE
MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy