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Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest

Schneider, Antoine G (författare)
Eastwood, Glenn M (författare)
Bellomo, Rinaldo (författare)
visa fler...
Bailey, Michael (författare)
Lipcsey, Miklos (författare)
Uppsala universitet,Anestesiologi och intensivvård
Pilcher, David (författare)
Young, Paul (författare)
Stow, Peter (författare)
Santamaria, John (författare)
Stachowski, Edward (författare)
Suzuki, Satoshi (författare)
Woinarski, Nicholas C (författare)
Pilcher, Janine (författare)
visa färre...
 (creator_code:org_t)
2013
2013
Engelska.
Ingår i: Resuscitation. - 0300-9572 .- 1873-1570. ; 84:7, s. 927-934
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BackgroundArterial carbon dioxide tension (PaCO2) affects neuronal function and cerebral blood flow. However, its association with outcome in patients admitted to intensive care unit (ICU) after cardiac arrest (CA) has not been evaluated.Methods and resultsObservational cohort study using data from the Australian New Zealand (ANZ) Intensive Care Society Adult-Patient-Database (ANZICS-APD). Outcomes analyses were adjusted for illness severity, co-morbidities, hypothermia, treatment limitations, age, year of admission, glucose, source of admission, PaO2 and propensity score.We studied 16,542 consecutive patients admitted to 125 ANZ ICUs after CA between 2000 and 2011. Using the APD-PaCO2 (obtained within 24 h of ICU admission), 3010 (18.2%) were classified into the hypo- (PaCO2 < 35 mmHg), 6705 (40.5%) into the normo- (35–45 mmHg) and 6827 (41.3%) into the hypercapnia (>45 mmHg) group. The hypocapnia group, compared with the normocapnia group, had a trend toward higher in-hospital mortality (OR 1.12 [95% CI 1.00–1.24, p = 0.04]), lower rate of discharge home (OR 0.81 [0.70–0.94, p < 0.01]) and higher likelihood of fulfilling composite adverse outcome of death and no discharge home (OR 1.23 [1.10–1.37, p < 0.001]). In contrast, the hypercapnia group had similar in-hospital mortality (OR 1.06 [0.97–1.15, p = 0.19]) but higher rate of discharge home among survivors (OR 1.16 [1.03–1.32, p = 0.01]) and similar likelihood of fulfilling the composite outcome (OR 0.97 [0.89–1.06, p = 0.52]). Cox-proportional hazards modelling supported these findings.ConclusionsHypo- and hypercapnia are common after ICU admission post-CA. Compared with normocapnia, hypocapnia was independently associated with worse clinical outcomes and hypercapnia a greater likelihood of discharge home among survivors.

Nyckelord

Hypocapnia
Hypercapnia
Carbon dioxide
Cardiac arrest
Resuscitation
Mortality
Outcome
Intensive care

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