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Sökning: onr:"swepub:oai:DiVA.org:uu-199936" > Membranous expressi...

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

Boman, K (författare)
Larsson, A H (författare)
Segersten, Ulrika, (författare)
Uppsala universitet, Urologkirurgi
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Kuteeva, E (författare)
Johannesson, H (författare)
Nodin, B (författare)
Eberhard, J (författare)
Uhlén, M (författare)
Malmström, Per-Uno, (författare)
Uppsala universitet, Urologkirurgi
Jirström, K (författare)
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2013
Engelska.
Ingår i: British Journal of Cancer. - 0007-0920 .- 1532-1827. ; 108, s. 2321-2328
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p><strong>Background:</strong></p><p>Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.</p><p><strong>Methods:</strong></p><p>Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n=100 (Cohort I) and n=343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed.</p><p><strong>Results:</strong></p><p>Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR=2.25 in Cohort I and 3.10 in Cohort II, adjusted HR=2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR=4.36, adjusted HR=2.70). In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR=6.19, adjusted HR=4.60) and DSS (unadjusted HR=8.34, adjusted HR=7.16).</p><p><strong>Conclusion:</strong></p><p>Membranous PODXL expression is an independent risk factor for progressive disease and death in patients with urothelial bladder cancer.</p>

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MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

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